SWI/SNF Chromatin Remodeling Complex
There are several large multi-subunit complexes that couple ATP hydrolysis with regulation of the chromatin landscape and are referred to as ATP-dependent chromatin remodelers. These complexes are primarily divided into four major classes based on the domain organization of their catalytic subunit. In this entry we focus on one of those major classes called the SWI/SNF subfamily. The SWI/SNF subfamily of chromatin remodelers are well conserved throughout all eukaryotes and typically the catalytic subunit has at least four signature motifs that are the ATPase, bromo, AT-hook, and HSA domains. The ATPase domain has sequence homology with the two lobes of such ATP-dependent DNA translocases like RecA and Rad54. The DNA translocation activity of SWI/SNF is essential for these complexes to move nucleosomes along DNA. The bromo domain binds to acetylated lysines in histone tails which may modulate the...