Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Angiotensin Type 2 Receptor

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_451


Historical Background

The angiotensin II type 2 receptor (AT2R) shares a high degree of homology with its well-known sister gene, the angiotensin II type 1 receptor (AT1R), and is similarly a part of the renin-angiotensin II system (RAS). The RAS is best known for its powerful effects on regulation of blood pressure and body fluid volume. The AT2R is activated after specific binding of the eight amino acid peptide angiotensin II (AngII), which is generated from angiotensin I by the angiotensin-converting enzyme. The AT2R is a member of the family of seven transmembrane receptors, the largest group of cell surface receptors in the body. Like its family members, the AT2R traverses the cell membrane seven times creating an NH2-terminal and three loops on the extracellular side and a COOH-terminal plus three loops on the intracellular side. The AT2R is present on multiple different cell types, although its expression level is often lower than that...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Clinical Biochemistry and PharmacologyOdense University Hospital, University of Southern DenmarkOdenseDenmark