Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Angiotensin Type 2 Receptor

  • Søren Paludan Sheikh
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_451

Synonyms

Historical Background

The angiotensin II type 2 receptor (AT2R) shares a high degree of homology with its well-known sister gene, the angiotensin II type 1 receptor (AT1R), and is similarly a part of the renin-angiotensin II system (RAS). The RAS is best known for its powerful effects on regulation of blood pressure and body fluid volume. The AT2R is activated after specific binding of the eight amino acid peptide angiotensin II (AngII), which is generated from angiotensin I by the angiotensin-converting enzyme. The AT2R is a member of the family of seven transmembrane receptors, the largest group of cell surface receptors in the body. Like its family members, the AT2R traverses the cell membrane seven times creating an NH2-terminal and three loops on the extracellular side and a COOH-terminal plus three loops on the intracellular side. The AT2R is present on multiple different cell types, although its expression level is often lower than that...

This is a preview of subscription content, log in to check access.

References

  1. Alterman MJ. Development of selective non-peptide angiotensin II type 2 receptor agonists. J Renin Angiotensin Aldosterone Syst. 2010;11(1):57–66. Epub 2009 Oct 30.PubMedCrossRefGoogle Scholar
  2. Bosnyak S, Welungoda IK, Hallberg A, Alterman M, Widdop RE, Jones ES. Stimulation of angiotensin AT2 receptors by the non-peptide agonist, compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol. 2010;159(3):709–16. Epub 2010 Jan 28.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Clere N, Corre I, Faure S, Guihot AL, Vessières E, Chalopin M, et al. Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis. Int J Cancer. 2010;127:2279–91.PubMedCrossRefGoogle Scholar
  4. Fujita T, Mogi M, Min LJ, Iwanami J, Tsukuda K, Sakata A, et al. Attenuation of cuff-induced neointimal formation by overexpression of angiotensin II type 2 receptor-interacting protein 1. Hypertension. 2009;53:688–93. Epub 2009 Feb 16.PubMedCrossRefGoogle Scholar
  5. Gembardt F, Heringer-Walther S, van Esch JH, Sterner-Kock A, van Veghel R, Le TH, et al. Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. FASEB J. 2008;22:3068–77. Epub 2008 May 22.PubMedCrossRefGoogle Scholar
  6. Guilluy C, Rolli-Derkinderen M, Loufrani L, Bourgé A, Henrion D, Sabourin L, et al. Ste20-related kinase SLK phosphorylates ser188 of rhoA to induce vasodilation in response to angiotensin II type 2 receptor activation. Circ Res. 2008;102:1265–74. Epub 2008 Apr 17.PubMedCrossRefGoogle Scholar
  7. Guimond MO, Roberge C, Gallo-Payet N. Fyn is involved in angiotensin II type 2 receptor-induced neurite outgrowth, but not in p42/p44mapk in NG108-15 cells. Mol Cell Neurosci. 2010;45:201–12. Epub 2010 Jun 25.PubMedCrossRefGoogle Scholar
  8. Jiang XY, Gao GD, XJ D, Zhou J, Wang XF, Lin YX. The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts. Acta Cardiol. 2007;62(5):429–38.PubMedCrossRefGoogle Scholar
  9. Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, Rompe F, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation. 2008;118:2523–32. Epub 2008 Nov 24.PubMedCrossRefGoogle Scholar
  10. Kawachi H, Han GD, Miyauchi N, Hashimoto T, Suzuki K, Shimizu F. Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy. J Nephrol. 2009;22:450–6.PubMedPubMedCentralGoogle Scholar
  11. Li H, Qi Y, Li C, Braseth LN, Gao Y, Shabashvili AE, et al. Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells. Mol Cancer Ther. 2009;8:3255–65.PubMedCrossRefGoogle Scholar
  12. Naito T, Ma LJ, Yang H, Zuo Y, Tang Y, Han JY, et al. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Am J Physiol Renal Physiol. 2010;298:F683–91. Epub 2009 Dec 30.PubMedCrossRefGoogle Scholar
  13. Ohinata K, Fujiwara Y, Fukumoto S, Iwai M, Horiuchi M, Yoshikawa M. Angiotensin II and III suppress food intake via angiotensin AT(2) receptor and prostaglandin EP(4) receptor in mice. FEBS Lett. 2008;582:773–7. Epub 2008 Feb 5.PubMedCrossRefGoogle Scholar
  14. Pawlowski TL, Heringer-Walther S, Cheng CH, Archie JG, Chen CF, Walther T, et al. Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Genomics. 2009;94:188–95. Epub 2009 Jun 6.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Pedersen-Bjergaard U, Dhamrait SS, Sethi AA, Frandsen E, Nordestgaard BG, Montgomery HE, et al. Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes. Am J Med. 2008;121:246.e1–8.CrossRefGoogle Scholar
  16. Rodrigues-Ferreira S, Nahmias C. An ATIPical family of angiotensin II AT2 receptor-interacting protein. Trends Endocrinol Metab. 2010;21:684–90.PubMedCrossRefGoogle Scholar
  17. Rompe F, Unger T, Steckelings UM. The angiotensin AT2 receptor in inflammation. Drug News Perspect. 2010;23:104–11.PubMedCrossRefGoogle Scholar
  18. Tesanovic S, Vinh A, Gaspari TA, Casley D, Widdop RE. Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2010;30:1606–13. Epub 2010 May 6.PubMedCrossRefGoogle Scholar
  19. Tousoulis D, Koumallos N, Antoniades C, Antonopoulos AS, Bakogiannis C, Milliou A, et al. Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males. Am J Hypertens. 2010;23:237–42. Epub 2009 Dec 3.PubMedCrossRefGoogle Scholar
  20. Ulmasov B, Xu Z, Tetri LH, Inagami T, Neuschwander-Tetri BA. Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2009;296:G284–94. Epub 2008 Nov 25.PubMedCrossRefGoogle Scholar
  21. Wenzel UO, Krebs C, Benndorf R. The angiotensin II type 2 receptor in renal disease. J Renin Angiotensin Aldosterone Syst. 2010;11:37–41.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Clinical Biochemistry and PharmacologyOdense University Hospital, University of Southern DenmarkOdenseDenmark