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IkBz

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References

  • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4(7):499–511.

    Article  PubMed  CAS  Google Scholar 

  • Basith S, Manavalan B, Gosu V, Choi S. Evolutionary, structural and functional interplay of the IkappaB family members. PLoS One. 2013;8(1):e54178.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, et al. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene. 1999;18(22):3316–23.

    Article  CAS  PubMed  Google Scholar 

  • Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev. 1993;7(7B):1354–63.

    Article  CAS  PubMed  Google Scholar 

  • Haruta H, Kato A, Todokoro K. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. J Biol Chem. 2001;276(16):12485–8.

    Article  CAS  PubMed  Google Scholar 

  • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132(3):344–62.

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev. 2006;210:171–86.

    Article  PubMed  Google Scholar 

  • Ishiguro-Oonuma T, Ochiai K, Hashizume K, Iwanaga T, Morimatsu M. Nfkbiz regulates the proliferation and differentiation of keratinocytes. Jpn J Vet Res. 2015;63(3):107–14.

    PubMed  Google Scholar 

  • Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, et al. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta. J Biol Chem. 2008;283(18):12468–77.

    Article  CAS  PubMed  Google Scholar 

  • Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M. MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000;485(1):53–6.

    Article  CAS  PubMed  Google Scholar 

  • Kuwata H, Matsumoto M, Atarashi K, Morishita H, Hirotani T, Koga R, et al. IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity. 2006;24(1):41–51.

    Article  CAS  PubMed  Google Scholar 

  • Lycan DE, Stafford KA, Bollinger W, Breeden LL. A new Saccharomyces cerevisiae ankyrin repeat-encoding gene required for a normal rate of cell proliferation. Gene. 1996;171(1):33–40.

    Article  CAS  PubMed  Google Scholar 

  • Manavalan B, Basith S, Choi YM, Lee G, Choi S. Structure-function relationship of cytoplasmic and nuclear IkappaB proteins: an in silico analysis. PLoS One. 2010;5(12):e15782.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Manavalan B, Govindaraj R, Lee G, Choi S. Molecular modeling-based evaluation of dual function of IkappaBzeta ankyrin repeat domain in toll-like receptor signaling. J Mol Recognit. 2011;24(4):597–607.

    Article  CAS  PubMed  Google Scholar 

  • Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Muller CW. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. EMBO J. 2001;20(22):6180–90.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mosavi LK, Cammett TJ, Desrosiers DC, Peng ZY. The ankyrin repeat as molecular architecture for protein recognition. Protein Sci. 2004;13(6):1435–48.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Motoyama M, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T. Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein. J Biol Chem. 2005;280(9):7444–51.

    Article  CAS  PubMed  Google Scholar 

  • Muta T. IkappaB-zeta: an inducible regulator of nuclear factor-kappaB. Vitam Horm. 2006;74:301–16.

    Article  CAS  PubMed  Google Scholar 

  • O’Shea JM, Perkins ND. Regulation of the RelA (p65) transactivation domain. Biochem Soc Trans. 2008;36(Pt 4):603–8.

    Article  CAS  PubMed  Google Scholar 

  • Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, et al. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010;464(7293):1381–5.

    Article  CAS  PubMed  Google Scholar 

  • Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem. 2006;281(18):12645–54.

    Article  CAS  PubMed  Google Scholar 

  • Wu Z, Zhang X, Yang J, Wu G, Zhang Y, Yuan Y, et al. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochem Biophys Res Commun. 2009;387(2):348–52.

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004;430(6996):218–22.

    Article  CAS  PubMed  Google Scholar 

  • Yamazaki S, Takeshige K. Protein synthesis inhibitors enhance the expression of mRNAs for early inducible inflammatory genes via mRNA stabilization. Biochim Biophys Acta. 2008;1779(2):108–14.

    CAS  PubMed  Google Scholar 

  • Yamazaki S, Muta T, Takeshige K. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J Biol Chem. 2001;276(29):27657–62.

    Article  CAS  PubMed  Google Scholar 

  • Yamazaki S, Muta T, Matsuo S, Takeshige K. Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization. J Biol Chem. 2005;280(2):1678–87.

    Article  CAS  PubMed  Google Scholar 

  • Yamazaki S, Matsuo S, Muta T, Yamamoto M, Akira S, Takeshige K. Gene-specific requirement of a nuclear protein, IkappaB-zeta, for promoter association of inflammatory transcription regulators. J Biol Chem. 2008;283(47):32404–11.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059).

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Correspondence to Sangdun Choi .

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Manavalan, B., Basith, S., Choi, S. (2018). IkBz. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_436

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