Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

S100 Proteins

  • Brian R. Dempsey
  • Anne C. Rintala-Dempsey
  • Gary S. ShawEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_426


S100 Protein Family Members

S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7, S100A8, S100A9, S100A10, S100A11, S100A12, S100A13, S100A14, S100A15, S100A16, S100B, S100P, S100G, S100Z, trichohyalin, filaggrin, filaggrin-2, cornulin, repetin

Historical Background/General: S100 Family

S100 proteins were first discovered in 1965 by Moore as a major protein fraction (0.6% of total soluble protein) isolated from bovine brain (Moore 1965). The protein was given the name S100 due to its high solubility in saturated ammonium sulfate. Later experiments showed the S100 protein fraction constituted two different dimeric species comprised of two β protomers (S100B) or an α,β heterodimer (Isobe et al. 1977). Early members of the S100 protein family were frequently given suffixes based on their localization or molecular size and included S100P (placental), S100C (cardiac or calgizzarin), p11 (11 kDa), and MRP8/MRP14 (myeloid regulatory proteins, 8 and 14...
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© Springer International Publishing AG 2018

Authors and Affiliations

  • Brian R. Dempsey
    • 1
  • Anne C. Rintala-Dempsey
    • 1
  • Gary S. Shaw
    • 2
    Email author
  1. 1.Department of Chemistry and BiochemistryUniversity of LethbridgeLethbridgeCanada
  2. 2.Department of BiochemistryThe University of Western OntarioLondonCanada