Synonyms
Historical Background
Phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) is an enzyme activity capable of converting a monophosphorylated lipid substrate into a bisphosphorylated product, a reaction that is fundamental in the maintenance of the cellular phosphoinositide (PI) cycle. PI5P4K catalyzes the addition of a phosphate group to position D-4 of the inositol head-group of PtdIns5P (Figs. 1 and 2). Downstream effects of signaling molecules generated by the PI cycle are diverse and include vesicle trafficking, ion channel activity, cytoskeletal dynamics, cell differentiation, proliferation, and apoptosis (Di Paolo and De Camilli 2006; Balla 2016; Viaud et al. 2016).
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Clarke, J.H., Irvine, R.F. (2018). Phosphatidylinositol 5-Phosphate 4-Kinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_418
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DOI: https://doi.org/10.1007/978-3-319-67199-4_418
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