Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Laurén B. Kinner-Bibeau
  • Sudesh Pawaria
  • Robert J. BinderEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_413


Historical Background

CD91, also known as the low density lipoprotein receptor-related protein 1 (LRP1), is a receptor on the plasma membrane involved in receptor-mediated endocytosis and in various signaling events. CD91 is a member of a gene family found in diverse species, including C. elegans, Drosophila, Xenopus, and mammals (Gaultier et al. 2008). Seven structurally closely related cell surface receptors constitute the core of the low density lipoprotein (LDL) receptor gene family. They include the LDL receptor, the LDL receptor-related protein (CD91), LRP1b, megalin, very low density lipoprotein (VLDL) receptor, apolipoprotein E receptor 2 (apo-ER2), and multiple epidermal growth factor-like domains containing protein 7 (MEGF7) (Herz and Strickland 2001). This review focuses on CD91 and its role as a signaling receptor for several...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Laurén B. Kinner-Bibeau
    • 1
  • Sudesh Pawaria
    • 2
  • Robert J. Binder
    • 1
    Email author
  1. 1.Department of ImmunologyUniversity of PittsburghPittsburghUSA
  2. 2.Department of MicrobiologyUniversity of Massachusetts Medical SchoolWorcesterUSA