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Encyclopedia of Signaling Molecules pp 1065–1074Cite as

Chemokine Receptor CCR1

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Synonyms

CCR-1; CD191; CC-CKR-1; CKR1; CMKBR1; HM145; MIP1aR

Definition

Chemokines represent a large group of chemotactic proteins, with more than 50 members that regulate the trafficking and activation of immune cells. They mediate their activity by binding to cell surface chemokine receptors that belong to the G-protein coupled receptor (GPCR) superfamily. CCR1 is a chemokine receptor that responds to a large number of CC chemokines including CCL3 (MIP-1alpha), CCL5 (RANTES), CCL7 (MCP-3), CCL9 (MIP-1gamma), CCL15 (MIP1 delta), CCL23 (MIP-3), and with low affinity to CCL4 (MIP-1 beta) and CCL8 (MCP-2).

Structure and Functions

Human CCR1 is a serpentine protein comprising of 355 amino acids with three potential glycosylation sites and the characteristic seven membrane spanning architecture typical of GPCR’s (Fig. 1). The receptor has a consensus site for tyrosine sulfation, which affects the affinity and binding of some chemokine receptors to their ligand(s) and has been hypothesized...

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Authors and Affiliations

  1. Department of Pharmacology, UC Davis, 451 Health Sciences Drive, 95616, Davis, CA, USA

    Richard Horuk

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  1. Richard Horuk
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Correspondence to Richard Horuk .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Horuk, R. (2018). Chemokine Receptor CCR1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_406

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