Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Myosin X

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_404


Historical Background

In 1994, myoX was first identified in a PCR screen designed to find novel  myosins in the inner ear (Solc et al. 1994). The full-length cDNA sequences of myoX were determined in 2000 in mouse (Yonezawa et al. 2000), human, and cow (Berg et al. 2000), and the molecular structure and ubiquitous expression in tissues were reported (Berg et al. 2000; Yonezawa et al. 2000). The unique localization pattern of myoX in cultured cells at the tips of filopodia and in lamellipodia was identified in the same reports (Berg et al. 2000; Yonezawa et al. 2000). Subsequently, in 2001, it was shown that the head domain of myoX binds actin and hydrolyzes ATP to induce movement and force (Homma et al. 2001). In 2002, myoX was shown to participate in intrafilopodial movement and filopodia formation (Berg and Cheney 2002), and in phagocytosis (Cox et al. 2002). After these breakthroughs, studies of myoX were expanded to many different aspects by precise...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Boston Biomedical Research InstituteWatertownUSA