Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

DLK (Dual Leucine Zipper-Bearing Kinase)

  • Richard BlouinEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_402


Historical Background

DLK is a serine/threonine kinase that belongs to the mixed-lineage kinase (MLK) family of mitogen-activated protein kinase kinase kinases (MAPKKKs) (Gallo and Johnson 2002). It was discovered in 1994 as a protein differentially expressed during the retinoic acid-induced neuronal differentiation of human NT2 teratocarcinoma cells and originally denoted zipper protein kinase (ZPK) (Reddy and Pleasure 1994). Parallel and subsequent studies led to the identification and cloning of the mouse and rat homologs of ZPK, respectively, termed DLK (Holzman et al. 1994) and MAP kinase upstream kinase (MUK) (Hirai et al. 1996).

Structure, Expression, and Subcellular Localization

DLK is a protein of about 120 kDa that shares with other...
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We thank Dr. Alain Lavigueur for critical reading of the manuscript and the Natural Sciences and Engineering Research Council of Canada for its financial support. We also apologize to our colleagues whose work could not be cited due to space limitations.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Département de biologieUniversité de SherbrookeSherbrookeCanada