Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Inositol 1,4,5-Trisphosphate-Associated cGMP Kinase Substrate

  • Michael A. Grillo
  • Peter KoulenEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_373


Historical Background

Inositol 1,4,5-trisphosphate (IP3) receptor-associated cyclic GMP (cGMP) kinase substrate (IRAG) is a 125-kD type 2 integral endoplasmic reticulum (ER) membrane protein. IRAG is 900 amino acids long and encoded by the Mrvi1 gene. Two splice variants exist in both mouse and humans with the IRAGa isoform containing an extra 84 amino acids in the N-terminus. Both variants contain a C-terminal hydrophobic domain, α-helix coiled-coil domain, basic N-terminal region, and multiple glycosylation and phosphorylation sites (Ammendola et al. 2001; Schlossmann et al. 2000; Shaughnessy et al. 1999). IRAG forms a complex with the inositol 1,4,5-trisphosphate receptor (IP3R) and cGMP kinase I-β (cGKIβ) and is involved in nitric oxide (NO), cGMP, and cGKIβ signaling pathways. IRAG...

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This chapter is part of the Encyclopedia of Signaling Molecules, 2nd Edition, and is based on a chapter of the same name previously published in the first edition of Encyclopedia of Signaling Molecules. This study was supported in part by grants EY014227 and EY022774 from NIH/NEI, RR022570 and RR027093 from NIH/NCRR and NIH/NIGMS, and AG010485, AG022550, and AG027956 from NIH/NIA, by the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research (PK). We thank Margaret, Richard, and Sara Koulen for their generous support and encouragement.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Ophthalmology and Department of Basic Medical ScienceUniversity of Missouri - Kansas City School of MedicineVision Research Center, Kansas CityUSA