Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Relaxin Family Peptide Receptors RXFP1 and RXFP2

  • Roger J. Summers
  • Michelle L. Halls
  • Ross A. D. Bathgate
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_362

Synonyms

 GREAT;  LGR7;  LGR8;  RXFP1;  RXFP2

Historical Background: Relaxin Family Peptides and Their Receptors

Relaxin was one of the first reproductive hormones to be identified, as a factor in the serum of pregnant guinea pigs that induced relaxation of the birth canal (Hisaw 1926). Until recently, relaxin was considered a hormone of pregnancy with little known of its roles in males and nonpregnant females. The isolation of relaxin from animal sources led to the determination of its structure, biological actions, and development of reliable bioassays (Schwabe and McDonald 1977; James et al. 1977; John et al. 1981), and this knowledge led to the use of recombinant DNA techniques to clone the rat (Hudson et al. 1981), pig (Haley et al. 1982), and human gene-1 (RLN1) (Hudson et al. 1983) and gene-2 relaxin (RLN2) genes (Hudson et al. 1984). The identification of other relaxin peptides and their cognate G protein-coupled receptors (GPCRs), more than 75 years after the identification...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Roger J. Summers
    • 1
  • Michelle L. Halls
    • 1
  • Ross A. D. Bathgate
    • 2
  1. 1.Drug Discovery Biology, Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleAustralia
  2. 2.Neuropeptides Division, Florey Institute of Neuroscience and Mental Health and Department of Biochemistry and Molecular BiologyUniversity of MelbourneParkvilleAustralia