Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Christopher T. Cottage
  • Balaji Sundararaman
  • Shabana Din
  • Nirmala Hariharan
  • Mark A. SussmanEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_344


Historical Background

The serine-threonine kinase Pim-1 belongs to the Calmodulin-dependent protein kinase family together with two other highly conserved family members (Pim-2 and Pim-3). Pim-1 is the preferential site of integration for the Moloney murine leukemia virus (Proviral Integration for Moloney Virus) discovered over 25 years ago (Selten et al. 1985). Pim-1 plays pivotal roles in cellular proliferation, differentiation, metabolism, and survival by phosphorylating and interacting with many targets. A literature search reveals the dynamic expression and activity of Pim-1 depends upon cell type and response to stimuli, either pathologic or homeostatic. Specifically, Pim-1 is expressed in various hematopoietic sites including thymus, spleen, bone marrow, and fetal liver, but can also be found in the heart, oral epithelia, prostate, hippocampus, vascular smooth muscle, and many tumorigenic cell types...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Christopher T. Cottage
    • 1
  • Balaji Sundararaman
    • 1
  • Shabana Din
    • 1
  • Nirmala Hariharan
    • 1
  • Mark A. Sussman
    • 2
    Email author
  1. 1.San Diego State Heart InstituteSan Diego State UniversitySan DiegoUSA
  2. 2.SDSU Heart InstituteSan Diego State University Biology DepartmentSan DiegoUSA