Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Richard VaillancourtEmail author
  • Annina C. Spilker
  • Morag Park
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_340

Historical Background

Gab proteins are scaffold proteins that are related to the insulin receptor substrates (IRS1/2/3), the fibroblast growth factor ( FGF) receptor substrate 2 (FRS2-α/β), the downstream of kinase (Dok), and the linker of T cell ( LAT). These proteins lack intrinsic enzymatic activity. Upon their recruitment to activated growth factor and cytokine receptors, they become tyrosine phosphorylated, providing binding sites for multiple proteins involved in signal transduction. By virtue of their ability to assemble multiprotein complexes, they act to modulate, amplify, and diversify the signals downstream from receptors (Pawson and Scott 1997; Schlessinger and Lemmon 2003).

The Gab family comprises three mammalian members, Gab1, Gab2, Gab3 (Fig. 1), the Drosophila melanogaster DOS (daughter of sevenless), and the Caenorhabditis elegansSOC-1. Gab1 was first identified in a screen for Grb2 binding proteins and was found to be a substrate for the EGF, TrkA, and insulin...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Richard Vaillancourt
    • 1
    • 2
    Email author
  • Annina C. Spilker
    • 1
    • 2
  • Morag Park
    • 1
    • 2
    • 3
    • 4
  1. 1.Goodman Cancer Research CentreMcGill UniversityMontréalCanada
  2. 2.Department of BiochemistryMcGill UniversityMontréalCanada
  3. 3.Department of MedicineMcGill UniversityMontréalCanada
  4. 4.Department of OncologyMcGill UniversityMontréalCanada