Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Melissa Rodriguez
  • Stefan Siwko
  • Mingyao LiuEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_338


Historical Background

The prostate-specific G-protein-coupled receptor, PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). The main purpose of the search was to find prostate-specific genes with potential diagnostic utility. PSGR was selected due to its prostate-specific expression and its overexpression in prostate cancer, which was suggestive of biomarker potential. Initial research on this molecule focused on its expression pattern, regulation, and probable role as a biomarker for prostate cancer. For an in-depth summary, please refer to the previous edition of this encyclopedia. Since then, research has emerged on the underlying mechanisms of its role in prostate cancer initiation and progression and its potential ligands. Herein we provide a review and update on the PSGR literature.

PSGR as a...

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  1. Ashida S, Nakagawa H, Katagiri T, Furihata M, Iizumi M, Anazawa Y, et al. Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer:genome-wide gene-expression profiles of prostate cancers and PINs. Cancer Res. 2004;64(17):5963–72.CrossRefPubMedGoogle Scholar
  2. Cardillo MR, Di Silverio F. Prostate-specific G protein coupled receptor genes and STAG1/PMEPA1 in peripheral blood from patients with prostatic cancer. Int J Immunopathol Pharmacol. 2006;19(4):871–8.CrossRefPubMedGoogle Scholar
  3. Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA. Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature. 2015;527(7577):240–4.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Conzelmann S, Levai O, Bode B, Eisel U, Raming K, Breer H, et al. A novel brain receptor is expressed in a distinct population of olfactory sensory neurons. Eur J Neurosci. 2000;12(11):3926–34.CrossRefPubMedGoogle Scholar
  5. Dong HW, Zhang S, Sun WG, Liu Q, Ibla JC, Soriano SG, et al. Beta-ionone arrests cell cycle of gastric carcinoma cells by a MAPK pathway. Arch Toxicol. 2013;87(10):1797–808.CrossRefPubMedGoogle Scholar
  6. Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem. 2009;284(24):16218–25.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci USA. 2013;110(11):4410–5.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Rigau M, Morote J, Mir MC, Ballesteros C, Ortega I, Sanchez A, et al. PSGR and PCA3 as biomarkers for the detection of prostate cancer in urine. Prostate. 2010;70(16):1760–7.PubMedGoogle Scholar
  9. Rigau M, Ortega I, Mir MC, Ballesteros C, Garcia M, Llaurado M, et al. A three-gene panel on urine increases PSA specificity in the detection of prostate cancer. Prostate. 2011;71(16):1736–45.CrossRefPubMedGoogle Scholar
  10. Rodriguez M, Luo W, Weng J, Zeng L, Yi Z, Siwko S, et al. PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-kappaB. Oncogene. 2014;3:e114.CrossRefGoogle Scholar
  11. Rodriguez M, Siwko S, Liu M. Prostate-specific G-protein coupled receptor, an emerging biomarker regulating inflammation and prostate cancer invasion. Curr Mol Med. 2016a;16(6):526–32.CrossRefPubMedGoogle Scholar
  12. Rodriguez M, Siwko S, Zeng L, Li J, Yi Z, Liu M. Prostate-specific G protein coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. Oncogene. 2016b;35(9):1153–62.CrossRefPubMedGoogle Scholar
  13. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a mammalian receptor repertoire. Sci Signal. 2009;2(60):ra9.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Sanz G, Leray I, Dewaele A, Sobilo J, Lerondel S, Bouet S, et al. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation. PLoS One. 2014;9(1):e85110.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Sequeiros T, Bastaros JM, Sanchez M, Rigau M, Montes M, Placer J, et al. Urinary biomarkers for the detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. Prostate. 2015;75(10):1102–13.CrossRefPubMedGoogle Scholar
  16. Shen MM, Abate-Shen C. Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 2010;24(18):1967–2000.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. Prostate. 2006;66(8):847–57.CrossRefPubMedGoogle Scholar
  18. Weng J, Ma W, Mitchell D, Zhang J, Liu M. Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. J Cell Biochem. 2005;96(5):1034–48.CrossRefPubMedGoogle Scholar
  19. Xia C, Ma W, Wang F, Hua S, Liu M. Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene. 2001;20(41):5903–7.CrossRefPubMedGoogle Scholar
  20. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, et al. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res. 2000;60(23):6568–72.PubMedGoogle Scholar
  21. Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ. Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Gene. 2001;278(1–2):41–51.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Mingyao Liu Lab Department of Molecular and Cellular MedicineInstitute of Biosciences and Technology, Texas A&M University Health Science CenterHoustonUSA
  2. 2.Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences, School of Life Sciences, East China Normal UniversityShanghaiChina