The prostate-specific G-protein-coupled receptor, PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). The main purpose of the search was to find prostate-specific genes with potential diagnostic utility. PSGR was selected due to its prostate-specific expression and its overexpression in prostate cancer, which was suggestive of biomarker potential. Initial research on this molecule focused on its expression pattern, regulation, and probable role as a biomarker for prostate cancer. For an in-depth summary, please refer to the previous edition of this encyclopedia. Since then, research has emerged on the underlying mechanisms of its role in prostate cancer initiation and progression and its potential ligands. Herein we provide a review and update on the PSGR literature.
PSGR as a...
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