Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Protein Tyrosine Kinase-6 (PTK6)

  • Amanda HarveyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_305


Historical Background

The intracellular protein tyrosine kinase, PTK6 (also known as the breast tumor kinase, Brk), has been implicated in the development and progression of a number of different tumor types. First identified in three separate studies in the early 1990s, it was initially found in a study to determine which tyrosine kinases were expressed in human melanocytes and then the full-length sequence was subsequently cloned from metastatic breast cancer using a screen to identify novel kinases that were expressed in tumors, but not normal breast tissue. Identification of the murine ortholog, sik, in mouse intestinal cells was achieved by the generation of a library of kinase catalytic domains.

PTK6 is related to the Src family of protein kinases and belongs to a distinct class of enzymes which includes Frk and SRMS (reviewed Harvey and Burmi 2011) and expression produces two different isoforms as a result of alternative splicing (reviewed in...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute for Environment Health and SocietiesBrunel UniversityLondonUK