Skip to main content
SpringerLink
Log in

Glutamate Receptor

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, Fang G, Irvine MW, Costa BM, Monaghan DT, Bortolotto ZA, Molnár E, Lodge D, Jane DE. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology. 2013;64:13–26.

    Article  PubMed  CAS  Google Scholar 

  • Copits BA, Swanson GT. Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function. Nat Rev Neurosci. 2012;13:657–86.

    Article  CAS  Google Scholar 

  • Diering GH, Heo S, Hussain NK, Liu B, Huganir RL. Extensive phosphorylation of AMPA receptors in neurons. Proc Nat Acad Sci USA. 2016;113:E4920–7.

    Article  CAS  Google Scholar 

  • Du J, Li X-H, Li Y-J. Glutamate in peripheral organs: biology and pharmacology. Eur J Pharmacol. 2016;784:42–8.

    Article  PubMed  CAS  Google Scholar 

  • Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR. Structural basis for integration of GluD receptors within synaptic organizer complexes. Science. 2016;353:295–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Galaz P, Barra R, Figueroa H, Mariqueo T. Advances in the pharmacology of IGIGs auxiliary subunits. Pharmacol Res. 2015;101:65–73.

    Article  PubMed  CAS  Google Scholar 

  • Gladding CM, Fitzjohn SM, Molnár E. Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms. Pharmacol Rev. 2009;61:395–412.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Golubeva AV, Moloney RD, O’Connor RM, Dinan TG, Cryan JF. Metabotropic glutamate receptors in central nervous system disorders. Curr Drug Targets. 2015;16:1–80.

    Google Scholar 

  • Gray JA, Zito K, Hell JW. Non-ionotropic signaling by the NMDA receptor: controversy and opportunity. F1000Research. 2016;5(F1000 Faculty Rev):1010.

    Google Scholar 

  • Haering SC, Tapken D, Pahl S, Hollmann M. Auxiliary subunits: shepherding AMPA receptors to the plasma membrane. Membranes. 2014;4:469–90.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Henley JM, Wilkinson KA. Synaptic AMPA receptor composition in development, plasticity and disease. Nat Rev Neurosci. 2016;17:337–50.

    Article  PubMed  CAS  Google Scholar 

  • Herguedas B, García-Nafría J, Cais O, Fernández-Leiro R, Krieger J, Ho H, Greger IH. Structure and organization of heteromeric AMPA-type glutamate receptors. Science. 2016;352:549.

    Article  CAS  Google Scholar 

  • Herguedas B, Krieger J, Greger IH. Receptor heteromeric assembly – how it works and why it matters: the case of ionotropic glutamate receptors. Prog Mol Biol Transl Sci. 2013;117:361–86.

    Article  PubMed  CAS  Google Scholar 

  • Howe JR. Modulation of non-NMDA receptor gating by auxiliary subunits. J Physiol. 2015;593:61–72.

    Article  PubMed  CAS  Google Scholar 

  • Huganir RL, Nicoll RA. AMPARs and synaptic plasticity: the last 25 years. Neuron. 2013;80:704–17.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kumar J, Mayer ML. Functional insights from glutamate receptor ion channel structures. Annu Rev Physiol. 2013;75:313–37.

    Article  PubMed  CAS  Google Scholar 

  • Lerma J, Marques JM. Kainate receptors in health and disease. Neuron. 2013;80:292–311.

    Article  PubMed  CAS  Google Scholar 

  • Levite M. Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren’s syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. J Neural Transm. 2014;121:1029–75.

    Article  PubMed  CAS  Google Scholar 

  • Lewerenz J, Maher P. Chronic glutamate toxicity in neurodegenerative diseases – what is the evidence? Front Neurosci. 2015;9:469.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lodge D. The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature. Neuropharmacology. 2009;56:6–21.

    Article  PubMed  CAS  Google Scholar 

  • Miladinovic T, Nashed MG, Singh G. Overview of glutamatergic dysregulation in central pathologies. Biomolecules. 2015;5:3112–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Molnár E. Molecular organization and regulation of glutamate receptors in developing and adult mammalian central nervous systems. In: Lajtha A, Vizi ES, editors. Handbook of neurochemistry and molecular neurobiology: neurotransmitter systems. 3rd ed. New York: Springer; 2008. p. 415–41.

    Chapter  Google Scholar 

  • Morris RGM. NMDA receptors and memory encoding. Neuropharmacology. 2013;74:32–40.

    Article  PubMed  CAS  Google Scholar 

  • Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP. Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology. 2011;60:1017–41.

    Article  PubMed  CAS  Google Scholar 

  • Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol. 2010;50:295–322.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Paoletti P, Bellone C, Zhou Q. NMDA receptor subunit diversity: impact on receptor proteins, synaptic plasticity and disease. Nat Rev Neurosci. 2013;14:383–400.

    Article  PubMed  CAS  Google Scholar 

  • Rondard P, Pin J-P. Dynamics and modulation of metabotropic glutamate receptors. Curr Opin Pharmacol. 2015;20:95–101.

    Article  PubMed  CAS  Google Scholar 

  • Sanz-Clemente A, Nicoll RA, Roche KW. Diversity in NMDA receptor composition: many regulators, many consequences. Neuroscientist. 2013;19:62–75.

    Article  PubMed  CAS  Google Scholar 

  • Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 2009;462:745–56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010;62:405–96.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, BS8 1TD, Bristol, UK

    Elek Molnár

Authors
  1. Elek Molnár
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elek Molnár .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Molnár, E. (2018). Glutamate Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_304

Download citation

Publish with us

Policies and ethics

Search

Navigation