Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Glutamate Receptor

  • Elek MolnárEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_304


Nomenclature of Glutamate Receptor Proteins

International Union of Basic and Clinical Pharmacology (IUPHAR) recommended and previous nomenclatures of glutamate receptor proteins
  1. 1.
    Ionotropic glutamate receptors (Traynelis et al. 2010)
    • AMPA receptor subunits GluA1–4 (previously: GluR1–4; GluRA-D; GLUA1-4)

    • Kainate receptor subunits GluK1–5 (previously: GluR5–7, KA-1/2; EAA3–5, EAA1/2; GLUK5-7, GLUK1/2)

    • NMDA receptor subunits GluN1, GluN2A-D, GluN3A-B (previously: NR1, NR2A-D, NR3A/B; GLUN1, GLUN2A-D, GLUN3A/B)

    • δ receptor subunits GluD1–2 (previously: GluRδ1/2)

  2. 2.
    Metabotropic glutamate receptors (Niswender and Conn 2010)
    • mGlu1–8 (previously: mGluR1–8)


Historical Background

The excitatory neurotransmitter role of L-glutamate gradually emerged in the 1950s–1960s. Early studies indicated that L-glutamate: (1) was present in high concentrations throughout the mammalian central...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Synaptic Plasticity, School of Physiology, Pharmacology and NeuroscienceUniversity of BristolBristolUK