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Encyclopedia of Signaling Molecules pp 2027–2040Cite as

GATA-3

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Synonyms

GATA-binding protein 3

Historical Background

Cellular fate during development, differentiation, and function is tightly regulated and orchestrated in a hierarchical fashion by transcriptional activators and repressors. GATA-3 is one such master regulator of cellular fate, which was identified in 1990 along with two other GATA-family members and was found to be abundantly expressed in T lymphocytes and the brain (Yamamoto et al. 1990). GATA-3 was first described as a transcription factor that interacts with the TCR-α gene enhancer (Ho et al. 1991). It belongs to the GATA family of transcription factors that are conserved proteins containing one or two C2-C2 type zinc fingers and a highly conserved C4 zinc finger that recognizes a consensus DNA sequence A/TGATAA/G from which the name of the family originated (Merika and Orkin 1993; Labastie et al. 1994). The mammalian GATA family of transcription factors consists of six members: GATA-binding protein 1 (GATA-1)–GATA-6. These...

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Acknowledgments

This work was supported by National Institutes of Health grants AI048927, AI106684 and HL113956 (to A.R.), and AI100012 and HL122307 (to P.R.).

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    Authors and Affiliations

    1. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA

      Anuradha Ray, Anupriya Khare & Prabir Ray

    2. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

      Nandini Krishnamoorthy

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    1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

      Sangdun Choi

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    Ray, A., Khare, A., Krishnamoorthy, N., Ray, P. (2018). GATA-3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_29

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