Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CARMA1

  • Hiromitsu Hara
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_297

Synonyms

Historical Background

The mucosa associated lymphoid tissue lymphoma (MALTL)-associated molecules, B-cell lymphoma 10 (BCL10) and MALTL translocation gene 1 (MALT1), form a complex and play an essential role in nuclear factor κB (NF-κB) activation through immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors and some G-protein-coupled receptors (Hara and Saito 2009). CARMA1 is a member of CARD-containing membrane-associated guanylate kinase (MAGUK) family and was found to be a binding partner of BCL10 via CARD-CARD interaction (Bertin et al. 2001; Gaide et al. 2001), similar to CARD9 and the other member of CARD-MAGUKs, CARMA2 and CARMA3. Among the CARD-MAGUK families, only CARMA1 is highly and selectively expressed in lymphoid organs such as thymus, lymph node, and spleen. It is thought that CARMA1 binds to BCL10-  MALT1...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Molecular and Cellular Immunoscience, Department of Biomolecular SciencesSaga UniversitySagaJapan