Ras-Related Associated with Diabetes
Ras associated with diabetes (Rad) was identified in the beginning of the 1990s as a clone differentially expressed in two subtraction cDNA libraries, which were prepared from skeletal muscle of normal individuals and patients with type II (noninsulin-dependent) diabetes mellitus (Reynet and Kahn 1993). Analysis of the newly identified clone revealed about 50% identity at the nucleotide level with members of the Ras superfamily, which consists of more than a 100 low-molecular-weight guanine nucleotide–binding proteins, also referred to as small GTPases. In their seminal report, Reynet and Kahn observed that the expression of Rad is typically highest in skeletal muscle, cardiac muscle, and lung of normal individuals. They also found that Rad mRNA levels in type II diabetes muscle are higher than in type I diabetes and nondiabetic muscle. These findings provided the framework for follow-up studies on the...
- Liao WL, Tan MW, Yuan Y, Wang GK, Wang C, Tang H, et al. Brahma-related gene 1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating Ras-related associated with diabetes in the pathophysiologic processes of aortic dissection. J Thorac Cardiovasc Surg. 2015;150:1292–301.PubMedPubMedCentralCrossRefGoogle Scholar