Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Ras-Related Associated with Diabetes

  • Jose-Luis González De AguilarEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_294


Historical Background

Ras associated with diabetes (Rad) was identified in the beginning of the 1990s as a clone differentially expressed in two subtraction cDNA libraries, which were prepared from skeletal muscle of normal individuals and patients with type II (noninsulin-dependent) diabetes mellitus (Reynet and Kahn 1993). Analysis of the newly identified clone revealed about 50% identity at the nucleotide level with members of the Ras superfamily, which consists of more than a 100 low-molecular-weight guanine nucleotide–binding proteins, also referred to as small GTPases. In their seminal report, Reynet and Kahn observed that the expression of Rad is typically highest in skeletal muscle, cardiac muscle, and lung of normal individuals. They also found that Rad mRNA levels in type II diabetes muscle are higher than in type I diabetes and nondiabetic muscle. These findings provided the framework for follow-up studies on the...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Faculty of Life SciencesUniversity of StrasbourgStrasbourgFrance
  2. 2.INSERM, U1118, Laboratory of Central and Peripheral Mechanisms of NeurodegenerationStrasbourgFrance