Cellular fate during development, differentiation, and function is tightly regulated and orchestrated in a hierarchical fashion by transcriptional activators and repressors. GATA-3 is one such master regulator of cellular fate, which was identified in 1990 along with two other GATA-family members and was found to be abundantly expressed in T lymphocytes and the brain (Yamamoto et al. 1990). GATA-3 was first described as a transcription factor that interacts with the TCR-α gene enhancer (Ho et al. 1991). It belongs to the GATA family of transcription factors that are conserved proteins containing one or two C2-C2 type zinc fingers and a highly conserved C4 zinc finger that recognizes a consensus DNA sequence A/TGATAA/G from which the name of the family originated (Merika and Orkin 1993; Labastie et al. 1994). The mammalian GATA family of transcription factors consists of six members: GATA-binding protein 1 (GATA-1)–GATA-6. These...
This work was supported by National Institutes of Health grants AI048927, AI106684 and HL113956 (to A.R.), and AI100012 and HL122307 (to P.R.).