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Encyclopedia of Signaling Molecules pp 2458–2481Cite as

HTR2B

  • Reference work entry
  • First Online:

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Synonyms

5-Hydroxytryptamine (serotonin) receptor 2B; 5-HT 2B receptor; 5-HT(2B); 5-HT-2B; 5-HT2B; Serotonin receptor 2B; 5-Hydroxytryptamine 2B receptor

Historical Background

Because of its exquisite sensitivity to serotonin, the rat stomach fundus was used as a bioassay for serotonin before the development of more quantitative analytical assays for this biogenic amine (Vane 1957). Although the potency for the contractile effects of serotonin has been known for long time, the receptors mediating such a response have eluded definitive characterization for long time. Pharmacological studies attempting to characterize the contractile serotonergic receptor in the rat stomach fundus documented the similarity to the 5-HT2C receptor. In the absence of detectable 5-HT2C receptor mRNA in the rat stomach fundus, only molecular cloning allowed the identification of a new receptor in 1992 in rat and mouse (Foguet et al. 1992; Kursar et al. 1992; Loric et al. 1992; Wainscott et al. 1993) and in...

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Authors and Affiliations

  1. Université Pierre et Marie Curie, Institut du Fer à Moulin, INSERM UMR-S 839, F75005, Paris, France

    Luc Maroteaux, Anne Roumier, Stéphane Doly & Silvina Laura Diaz

  2. Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), 37 Kent Street, 4102, Brisbane, QLD, Australia

    Arnauld Belmer

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  1. Luc Maroteaux
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  2. Anne Roumier
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  3. Stéphane Doly
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  4. Silvina Laura Diaz
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  5. Arnauld Belmer
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Correspondence to Luc Maroteaux .

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  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Maroteaux, L., Roumier, A., Doly, S., Diaz, S.L., Belmer, A. (2018). HTR2B. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_286

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