Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Luc MaroteauxEmail author
  • Anne Roumier
  • Stéphane Doly
  • Silvina Laura Diaz
  • Arnauld Belmer
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_286


Historical Background

Because of its exquisite sensitivity to serotonin, the rat stomach fundus was used as a bioassay for serotonin before the development of more quantitative analytical assays for this biogenic amine (Vane 1957). Although the potency for the contractile effects of serotonin has been known for long time, the receptors mediating such a response have eluded definitive characterization for long time. Pharmacological studies attempting to characterize the contractile serotonergic receptor in the rat stomach fundus documented the similarity to the 5-HT2C receptor. In the absence of detectable 5-HT2C receptor mRNA in the rat stomach fundus, only molecular cloning allowed the identification of a new receptor in 1992 in rat and mouse (Foguet et al. 1992; Kursar et al. 1992; Loric et al. 1992; Wainscott et al. 1993)...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Luc Maroteaux
    • 1
    Email author
  • Anne Roumier
    • 1
  • Stéphane Doly
    • 1
  • Silvina Laura Diaz
    • 1
  • Arnauld Belmer
    • 2
  1. 1.Université Pierre et Marie Curie, Institut du Fer à MoulinParisFrance
  2. 2.Institute of Health and Biomedical Innovation (IHBI)Queensland University of Technology (QUT)BrisbaneAustralia