Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Nuclear Receptor-Interacting Protein 1 (NRIP1)

  • Bomi Lee
  • Ping-Chih Ho
  • Li-Na WeiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_280


Historical Background

Determining the regulatory mechanisms of nuclear receptor action was one major focal topic of research in the 1990s. During this period, many nuclear receptor-associated proteins were identified as transcriptional coregulators, which were broadly categorized as coactivators and corepressors. Human receptor-interacting protein 140 (RIP140) was identified as a ligand-dependent interacting protein of estrogen receptor α (ERα) by far-Western blotting, and mouse RIP140 was isolated as a corepressor of orphan receptor TR2 from a yeast two-hybrid screening and later found to also interact with  retinoic acid receptor (RAR) in a ligand-enhanced manner (Lee et al. 1998). An official gene name nrip1was established for RIP140 by the HUGO gene nomenclature committee. The mouse gene is located on chromosome 16, in...

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This work was supported by DK54733, DK60521, DK54733-11S, DK60521-12S1, Dean’s Commitment, and the Distinguished McKnight University Professorship of University of Minnesota to LNW.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of Minnesota Medical SchoolMinneapolisUSA