Nuclear Receptor-Interacting Protein 1 (NRIP1)
Determining the regulatory mechanisms of nuclear receptor action was one major focal topic of research in the 1990s. During this period, many nuclear receptor-associated proteins were identified as transcriptional coregulators, which were broadly categorized as coactivators and corepressors. Human receptor-interacting protein 140 (RIP140) was identified as a ligand-dependent interacting protein of estrogen receptor α (ERα) by far-Western blotting, and mouse RIP140 was isolated as a corepressor of orphan receptor TR2 from a yeast two-hybrid screening and later found to also interact with retinoic acid receptor (RAR) in a ligand-enhanced manner (Lee et al. 1998). An official gene name nrip1was established for RIP140 by the HUGO gene nomenclature committee. The mouse gene is located on chromosome 16, in...
This work was supported by DK54733, DK60521, DK54733-11S, DK60521-12S1, Dean’s Commitment, and the Distinguished McKnight University Professorship of University of Minnesota to LNW.
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