Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Matthew D. Blunt
  • Stephen G. Ward
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_271


Historical Background

SH2 domain-containing inositol phosphatase-1 (SHIP) was initially identified in 1994 as a tyrosine-phosphorylated protein after stimulation of blood cells by a broad number of cytokines and growth factors (Lioubin et al. 1994; Liu et al. 1994). It translocates to the plasma membrane after extracellular stimulation and hydrolyses the  phosphoinositide 3-kinase (PI3K)-generated second messenger PI(3,4, 5)P3, to PI(3,4)P2. As a result, SHIP is able to modulate PI(3,4,5)P3-mediated signaling and hence the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. The creation of germ-line SHIP–/– knockout mice in 1998 was instrumental in determining the role SHIP plays in the immune system (Helgason et al. 1998). Subsequent cell-restricted deletion in lymphoid and myeloid compartments some 10 years later, further...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Matthew D. Blunt
    • 1
  • Stephen G. Ward
    • 2
  1. 1.Department of Pharmacy and PharmacologyUniversity of BathBathUK
  2. 2.Department of Pharmacy and PharmacologyUniversity of Bath, Claverton DownBathUK