Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Kirill A. MartemyanovEmail author
  • Pooja Parameswaran
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_259


Introduction and Historical Background

Regulator of G protein signaling (RGS) proteins constitute a diverse family with more than 30 members that contain the hallmark RGS domain. Most members serve as negative regulators of G protein signaling by catalyzing the GTP hydrolysis on Gα subunits leading to their inactivation (Ross and Wilkie 2000; Hollinger and Hepler 2002). Based on their structural organization and sequence homology RGS proteins are divided into five to six families (Ross and Wilkie 2000; Hollinger and Hepler 2002). The R7 RGS family (R7 RGS) contains multidomain proteins conserved from C. elegans to humans that, in mammals are represented by four members: RGS6, RGS7, RGS9, and RGS11. R7 RGS proteins play important roles in the nervous system by controlling neurotransmitter action at rhodopsin, μ-opioid, D2 dopamine, and GABA(B) receptors (Anderson et al. 2009a).

The unique feature of this group is that they...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of NeuroscienceThe Scripps Research InstituteJupiterUSA
  2. 2.Department of PharmacologyUniversity of MinnesotaMinneapolisUSA