Synonyms
Historical Background
Hippocalcin was originally cloned from a rat brain cDNA library based on the partial amino acid sequences from a calcium-binding protein with a molecular mass of 23,000 Da (P23k), which was purified during a survey of recoverin-like immunoreactivity in the brain (Kobayashi et al. 1992). During the 1990s, a number of calcium-binding proteins structurally related to hippocalcin were identified in the nervous system and named NCS (neuronal calcium sensor) proteins. There are 14 protein-coding genes in the NCS family in the human genome (Burgoyne 2007). Hippocalcin is a highly conserved protein and has an identical amino acid sequence in rat, mouse, bovine, and human (Kobayashi and Takamatsu 2009).
Protein Chemical Characteristics
Hippocalcin, a 23 kDa protein of 193 amino acid residues containing 10 α-helices and 2 antiparallel β-sheets, has three functional EF-hand calcium-binding domains and an N-terminal glycine residue covalently linked to myristic...
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References
Burgoyne RD. Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat Rev Neurosci. 2007;8:182–93. https://doi.org/10.1038/nrn2093.
Charlesworth G, Angelova PR, Bartolomé-Robledo F, Ryten M, Trabzuni D, Stamelou M, et al. Mutations in HPCA cause autosomal-recessive primary isolated dystonia. Am J Hum Genet. 2015;96:657–65. https://doi.org/10.1016/j.ajhg.2015.02.007.
Conesa-Zamora P, GarcÃa-Solano J, GarcÃa-GarcÃa F, Turpin Mdel C, Trujillo-Santos J, Torres-Moreno D, et al. Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma. Int J Cancer. 2013;132:297–307. https://doi.org/10.1002/ijc.27674.
Dovgan AV, Cherkas VP, Stepanyuk AR, Fitzgerald DJ, Haynes LP, Tepikin AV, Burgoyne RD, Belan PV. Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons. Eur J Neurosci. 2010;32:347–58. https://doi.org/10.1111/j.1460-9568.2010.07303.x.
Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Mol Cell Proteomics. 2009;8:1972–87. https://doi.org/10.1074/mcp.M800495-MCP200.
Kim KS, Duignan KM, Hawryluk JM, Soh H, Tzingounis AV. The voltage activation of cortical KCNQ channels depends on global PIP2 levels. Biophys J. 2016;110:1089–98. https://doi.org/10.1016/j.bpj.2016.01.006.
Kobayashi M, Takamatsu K. Hippocalcin. UCSD-Nature Molecule Pages. 2009; https://doi.org/10.1038/mp.a004097.01.
Kobayashi M, Takamatsu K, Saitoh S, Miura M, Noguchi T. Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus. Biochem Biophys Res Commun. 1992;189:511–7. https://doi.org/10.1016/0006-291X(92)91587-G.
Kobayashi M, Masaki T, Hori K, Masuo Y, Miyamoto M, Tsubokawa H, et al. Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory. Neuroscience. 2005;133:471–84. https://doi.org/10.1016/j.neuroscience.2005.02.034.
Kobayashi M, Hamanoue M, Masaki T, Furuta Y, Takamatsu K. Hippocalcin mediates calcium-dependent translocation of brain-type creatine kinase (BB-CK) in hippocampal neurons. Biochem Biophys Res Commun. 2012;429(3–4):142–7. https://doi.org/10.1016/j.bbrc.2012.10.125.
Li C, Ames JB. 1H, 13C, and 15N chemical shift assignments of neuronal calcium sensor protein, hippocalcin. Biomol NMR Assign. 2014;8:63–6. https://doi.org/10.1007/s12104-012-9453-3.
Lim YA, Giese M, Shepherd C, Halliday G, Kobayashi M, Takamatsu K, et al. Role of hippocalcin in mediating Aβ toxicity. Biochim Biophys Acta. 2012;1822:1247–57. https://doi.org/10.1016/j.bbadis.2012.04.007.
Lindholm D, Mercer EA, Yu LY, Chen Y, Kukkonen J, Korhonen L, et al. Neuronal apoptosis inhibitory protein: structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons. Biochim Biophys Acta. 2002;1600:138–47. https://doi.org/10.1016/S1570-9639(02)00454-5.
Mammen A, Simpson PJ, Mamman A, Simpson JP, Nighorn A, Imanishi Y, et al. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun. 2004;322:1131–9. https://doi.org/10.1016/j.bbrc.2004.07.123.
Markova O, Fitzgerald D, Stepanyuk A, Dovgan A, Cherkas V, Tepikin A, et al. Hippocalcin signaling via site-specific translocation in hippocampal neurons. Neurosci Lett. 2008;442:152–7. https://doi.org/10.1016/j.neulet.2008.06.089.
Nagao M, Hayashi H. Mixed lineage kinase 2 and hippocalcin are colocalized in Lewy bodies of Parkinson’s disease. J Neurol Sci. 2009;281:51–4. https://doi.org/10.1111/j.1471–4159.2009.06344.x.
O’Callaghan DW, Haynes LP, Burgoyne RD. High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate. Biochem J. 2005;391:231–8. https://doi.org/10.1042/BJ20051001.
Oh DY, Yon C, Oh KJ, Lee KS, Han JS. Hippocalcin increases phospholipase D2 expression through extracellular signal-regulated kinase activation and lysophosphatidic acid potentiates the hippocalcin-induced phospholipase D2 expression. J Cell Biochem. 2006;97:1052–65. https://doi.org/10.1002/jcb.20665.
Palmer CL, Lim W, Hastie PG, Toward M, Korolchuk VI, Burbidge SA, et al. Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron. 2005;47:487–94. https://doi.org/10.1016/j.neuron.2005.06.014.
Tzingounis AV, Kobayashi M, Takamatsu K, Nicoll RA. Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells. Neuron. 2007;53:487–93. https://doi.org/10.1016/j.neuron.2007.01.011.
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Kobayashi, M., Takamatsu, K. (2018). Hippocalcin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_251
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DOI: https://doi.org/10.1007/978-3-319-67199-4_251
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