Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MYLK (Myosin Light Chain Kinase)

  • Thomas J. LukasEmail author
  • Vladimir P. Shirinsky
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_248


Historical Background

The gene for myosin light chain kinase encodes three proteins: MLCK210, MLCK108, and telokin/kinase-related protein (KRP). The first protein discovered was MLCK108 (Mr = 110–140 kDa) as a major cytoplasmic component of smooth muscle and responsible for smooth muscle contractility through the phosphorylation of the regulatory light chain of myosin (Lukas et al. 1998; Kamm and Stull 2001). MLCK210 (Mr = 210–220 kDa) has an amino-terminal extension containing additional protein-binding elements (Fig. 1). It was discovered ∼15 years later before the gene for MYLK was characterized from chicken (Birukov et al. 1998) and humans (Shen et al. 2012). Both MLCKs are Ca 2+-calmodulin-dependent enzymes. Telokin/KRP is an independently expressed nonkinase gene product containing the C-terminus of MLCK, and functions as a myosin-binding and...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PharmacologyNorthwestern UniversityChicagoUSA
  2. 2.Institute of Experimental CardiologyRussian Cardiology Research and Production Complex, Ministry of Healthcare of Russian FederationMoscowRussia