MYLK (Myosin Light Chain Kinase)
Reference work entry
The gene for myosin light chain kinase encodes three proteins: MLCK210, MLCK108, and telokin/kinase-related protein (KRP). The first protein discovered was MLCK108 (Mr = 110–140 kDa) as a major cytoplasmic component of smooth muscle and responsible for smooth muscle contractility through the phosphorylation of the regulatory light chain of myosin (Lukas et al. 1998; Kamm and Stull 2001). MLCK210 (Mr = 210–220 kDa) has an amino-terminal extension containing additional protein-binding elements (Fig. 1). It was discovered ∼15 years later before the gene for MYLK was characterized from chicken (Birukov et al. 1998) and humans (Shen et al. 2012). Both MLCKs are Ca 2+-calmodulin-dependent enzymes. Telokin/KRP is an independently expressed nonkinase gene product containing the C-terminus of MLCK, and functions as a myosin-binding and...
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