Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Chotirat Rattanasinchai
  • Jian Chen
  • Kathleen A. GalloEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_247


Historical Background

The mixed-lineage kinases are so named for their sequence similarity to both tyrosine kinases and serine/threonine kinases. However, based on biochemical assays, only serine/threonine kinase activity has been demonstrated for the MLKs. The three subfamilies of MLKs reside within the “tyrosine kinase-like” branch of the human kinome. Members of the MLK subfamily, comprised of MLK1-4, share a conserved domain arrangement and 75% identity within their catalytic domains (Fig. 1). The dual leucine zipper–bearing kinase (DLK) subgroup of MLKs, which includes DLK/ZPK/MUK and LZK, is characterized by a kinase catalytic domain followed by two leucine zipper motifs. A third subgroup of MLKs represented by ZAK/MLTK contains both a leucine zipper motif and a sterile-alpha motif. MLK3 has emerged as the paradigm for the MLK...
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© Springer International Publishing AG 2018

Authors and Affiliations

  • Chotirat Rattanasinchai
    • 1
    • 2
  • Jian Chen
    • 3
    • 4
  • Kathleen A. Gallo
    • 1
    • 2
    Email author
  1. 1.Cell and Molecular Biology ProgramMichigan State UniversityEast LansingUSA
  2. 2.Department of PhysiologyMichigan State UniversityEast LansingUSA
  3. 3.Department of Biochemistry and Molecular BiologyMichigan State UniversityEast LansingUSA
  4. 4.Department of MedicineDuke UniversityDurhamUSA