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Encyclopedia of Signaling Molecules pp 3466–3475Cite as

NF-κB Family

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Synonyms

Nuclear factor-kappa-B; Nuclear factor of kappa light polypeptide gene enhancer in B cells

List of Discussed NF-κB Family Members and Regulatory Molecules

NFκB1: p105, p50, KBF1, EBP-1

RelA: p65, NFKB3

RelB: I-REL

REL: c-Rel

NFκB2: p100, p52; LYT10

Bcl-3: BCL4, D19S37

NFKBIA: IκBα, IKBA, MAD-3, NFKBI

NFKBIB: IκBβ, IKBB, TRIP9

NFKBIE: IκBε, IKBE

NFKBIZ: IκBζ, IKBZ, INAP, MAIL

CHUK: IKKα, IKBKA, IKK1, IKKA, NFKBIKA, TCF16

IKBKB: IKKβ, IKK2, IKKB, NFKBIKB

IKBKG: IKKγ, NEMO, AMCBX1, FIP-3, FIP3, Fip3p, IP, IP1, IP2, IPD2, IKKAP1, IKKG

IKBKE: IKKε, IKKE, IKKI

MAP3K14: NIK, HS, HSNIK

TNFAIP3: A20, OTUD7C, TNFA1P2

OTUD7B: CEZANNE

CYLD: HSPC057, CDMT, CYLD1, CYLDI, EAC, MFT1, SBS, TEM, USPL2

Historical Background: Discovery and Structure

NF-κB (nuclear factor-kappa-light-chain-enhancer of activated B cells) is a collective term for a family of transcription factors. NF-κB has a complex regulation, modulates the expression of a wide set of genes, both by promoting and by suppressing...

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NF-κB Family, Fig. 1
NF-κB Family, Fig. 2

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Authors and Affiliations

  1. IIS-Fundacion Jimenez Diaz, Madrid, Spain

    Lara Valiño-Rivas, Laura Gonzalez-Lafuente & Jonay Poveda

  2. IIS-Fundacion Jimenez Diaz and Universidad Autonoma de Madrid, Av Reyes Católicos 2, Madrid, 28040, Spain

    Ana B. Sanz, Alberto Ortiz & Maria D. Sanchez-Niño

Authors
  1. Lara Valiño-Rivas
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  2. Laura Gonzalez-Lafuente
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  3. Ana B. Sanz
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  4. Jonay Poveda
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  5. Alberto Ortiz
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  6. Maria D. Sanchez-Niño
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Corresponding author

Correspondence to Maria D. Sanchez-Niño .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Valiño-Rivas, L., Gonzalez-Lafuente, L., Sanz, A.B., Poveda, J., Ortiz, A., Sanchez-Niño, M.D. (2018). NF-κB Family. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_220

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