Skip to main content

Nucleotide Receptor P2Y

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abbracchio MP, Burnstock G, Boeynaems J-M, Barnard EA, Boyer JL, Kennedy C, et al. International Union of Pharmacology. Update and subclassification of the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006;58:281–341.

    Article  PubMed  CAS  Google Scholar 

  • Andre P, Delaney SM, LaRocca T, Vincent D, DeGuzman F, Jurek M, et al. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest. 2003;112:398–406.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Biver G, Wang N, Gartland A, Orriss I, Arnett TR, Boeynaems JM, Robaye B. Role of the P2Y13 Receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes. Stem Cells. 2013;31:2747–58.

    Article  CAS  PubMed  Google Scholar 

  • Bles N, Di Pietrantonio L, Boeynaems J-M, Communi D. ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion. Blood. 2010;116(17):3219–26.

    Article  CAS  PubMed  Google Scholar 

  • Burnstock G. A basis for distinguishing two types of purinergic receptor. In: Straub RW, Bolis L, editors. Cell membrane receptors for drugs and hormones: a multidisciplinary approach. New York: Raven Press; 1978. p. 107–18.

    Google Scholar 

  • Burnstock G, Kennedy C. Is there a basis for distinguishing two types of purinoceptor? Gen Pharmacol. 1985;16:433–40.

    Article  CAS  PubMed  Google Scholar 

  • Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, et al. A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000;275:10767–71.

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkermagel A, et al. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006;314:1792–5.

    Article  CAS  PubMed  Google Scholar 

  • Ciciarello M, Zini R, Rossi L, Salvestrini V, Ferrari D, Manfredini R, Lemoli RM. Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages. Stem Cells Dev. 2013;22:1097–111.

    Article  CAS  PubMed  Google Scholar 

  • Clouet S, di Pietrantonio L, Daskalopoulos EP, Esfahani H, Horckmans M, Vanorlé M, et al. Loss of mouse P2Y6 nucleotide receptor is associated with physiological macrocardia and amplified pathological cardiac hypertrophy. J Biol Chem. 2016;291(30):15841–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cohen R, Shainberg A, Hochhauser E, Cheporko Y, Tobar A, Birk E, et al. UTP reduces infarct size and improves mice heart function after myocardial infarct via P2Y2 receptor. Biochem Pharmacol. 2011;82(9):1126–33.

    Article  CAS  PubMed  Google Scholar 

  • Communi D, Pirotton S, Parmentier M, Boeynaems JM. Cloning and functional expression of a human uridine nucleotide receptor. J Biol Chem. 1995;270:30849–52.

    Article  CAS  PubMed  Google Scholar 

  • Communi D, Parmentier M, Boeynaems JM. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996;222:303–8.

    Article  CAS  PubMed  Google Scholar 

  • Communi D, Govaerts C, Parmentier M, Boeynaems JM. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem. 1997;272:31969–73.

    Article  CAS  PubMed  Google Scholar 

  • Communi D, Suarez-Huerta N, Dussossoy D, Savi P, Boeynaems JM. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. J Biol Chem. 2001a;276:16561–6.

    Article  CAS  PubMed  Google Scholar 

  • Communi D, Gonzalez NS, Detheux M, Brezillon S, Lannoy V, Parmentier M, Boeynaems JM. Identification of a novel human ADP receptor coupled to Gi. J Biol Chem. 2001b;276:41479–85.

    Article  CAS  PubMed  Google Scholar 

  • Cressman VL, Lazarowski E, Homolya L, Boucher RC, Koller BH, Grubb BR. Effect of loss of P2Y2 receptor gene expression on nucleotide regulation of murine epithelial Cl transport. J Biol Chem. 1999;274:26461–8.

    Article  CAS  PubMed  Google Scholar 

  • Drury AN, Szent-Györgyi A. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol. 1929;68:213–37.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461:282–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fabre AC, Malaval C, Ben Addi A, Verdier C, Pons V, Serhan N, et al. P2Y13 receptor is critical for reverse cholesterol transport. Hepatology. 2010;52:1477–83.

    Article  CAS  PubMed  Google Scholar 

  • Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci. 2006;9:1512–9.

    Article  PubMed  CAS  Google Scholar 

  • Hechler B, Freund M, Ravanat C, Magnenat S, Cazenave JP, Gachet C. Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors. Circulation. 2008;118:754–63.

    Article  CAS  PubMed  Google Scholar 

  • Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. 2001;409:202–7.

    Article  CAS  PubMed  Google Scholar 

  • Horckmans M, Robaye B, Léon-Gόmez E, Lantz N, Unger P, Dol-Gleizes F, et al. P2Y4 nucleotide receptor: a novel actor in post-natal cardiac development and function. Angiogenesis. 2012a;15:349–60.

    Article  CAS  PubMed  Google Scholar 

  • Horckmans M, Léon-Gomez E, Robaye B, Balligand JL, Boeynaems JM, Dessy C, Communi D. Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise. Am J Physiol Heart Circ Physiol. 2012b;303:835–43.

    Article  CAS  Google Scholar 

  • Horckmans M, Esfahani H, Beauloye C, Clouet S, di Pietrantonio L, Robaye R, et al. Loss of P2Y4 nucleotide receptor protect against myocardial infarction through endothelin-1 downregulation. J Immunol. 2015;194:1874–81.

    Article  CAS  PubMed  Google Scholar 

  • Jacquet S, Malaval C, Martinez LO, Sak K, Rolland C, Perez C, et al. The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis. Cell Mol Life Sci. 2005;62:2508–15.

    Article  CAS  PubMed  Google Scholar 

  • Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, et al. UDP acting at P2Y6 receptors is a novel mediator of microglial phagocytosis. Nature. 2007;446:1091–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Léon C, Hechler B, Freund M, Eckly A, Vial C, Ohlmann P, et al. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1 receptor-null mice. J Clin Invest. 1999;104:1731–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lustig KD, Shiau AK, Brake AJ, Julius D. Expression cloning of an ATP receptor from mouse neuroblasoma cells. Proc Natl Acad Sci. 1993;90:5113–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marteau F, Gonzalez NS, Communi D, Goldman M, Boeynaems J-M, Communi D. Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells. Blood. 2005;106:3860–6.

    Article  CAS  PubMed  Google Scholar 

  • Nishida M, Sato Y, Uemura A, Narita Y, Tozaki-Saitoh H, Nakaya M, Ide T, Suzuki K, Inoue K, Nagao T, Kurose H. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis. EMBO J. 2008;27:3104–15.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ratjen F, Durham T, Navratil T, Schaberg A, Accurso FJ, Wainwright C, et al. Long term effects of denufosol terasodium in patients with cystic fibrosis. J Cyst Fibros. 2012;11:539–49.

    Article  CAS  PubMed  Google Scholar 

  • Riegel AK, Faigle M, Zug S, Rosenberger P, Robaye B, Boeynaems J-M, et al. Selective induction of endothelial P2Y6 nucleotide recptor promotes vascular inflammation. Blood. 2011;117:2548–55.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Robaye B, Ghanem E, Wilkin F, Fokan D, Van Driessche W, Schurmans S, et al. Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice. Mol Pharmacol. 2003;63:777–83.

    Article  CAS  PubMed  Google Scholar 

  • Seye CI, Yu N, Gonzalez FA, Erb L, Weisman GA. The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1). J Biol Chem. 2004;279:35679–86.

    Article  CAS  PubMed  Google Scholar 

  • Vanderstocken G, Bondue B, Horckmans M, Di Pietrantonio L, Robaye B, Boeynaems J-M, Communi D. P2Y2 receptor regulates VCAM-1membrane and soluble forms and eosinophil accumulation during lung inflammation. J Immunol. 2010;185(6):3702–7.

    Article  CAS  PubMed  Google Scholar 

  • Waldo GL, Harden TK. Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor. Mol Pharmacol. 2004;65:426–36.

    Article  CAS  PubMed  Google Scholar 

  • Wang N, Robaye B, Agrawal A, Skerry TM, Boeynaems J-M, Gartland A. Reduced bone turnover in mice lacking the P2Y13 receptor of ADP. Mol Endocrinol. 2012;26:142–52.

    Article  CAS  PubMed  Google Scholar 

  • Webb TE, Simon J, Krishek BJ, Bateson AN, Smart TG, King BF, et al. Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett. 1993;324:219–25.

    Article  CAS  PubMed  Google Scholar 

  • Wilkin F, Duhant X, Bruyns C, Suarez-Huerta N, Boeynaems JM, Robaye B. The P2Y11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells. J Immunol. 2001;166:7172–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Didier Communi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Communi, D., Robaye, B., Boeynaems, JM. (2018). Nucleotide Receptor P2Y. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_198

Download citation

Publish with us

Policies and ethics