Skip to main content
SpringerLink
Log in

Neurotensin Receptor (NTSR)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 52 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci USA. 2005;102(38):13461–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Antonelli T, Fuxe K, Tomasini MC, Mazzoni E, Agnati LF, Tanganelli S, et al. Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment. Prog Neurobiol. 2007;83(2):92–109.

    Article  CAS  PubMed  Google Scholar 

  • Bakirtzi K, Hatziapostolou M, Karagiannides I, Polytarchou C, Jaeger S, Iliopoulos D, et al. Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology. 2011;141(5):1749–61.

    Article  CAS  Google Scholar 

  • Carraway R, Leeman SE. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem. 1973;248(19):6854–61.

    CAS  PubMed  Google Scholar 

  • Dobner PR. Multitasking with neurotensin in the central nervous system. Cell Mol Life Sci. 2005;62(17):1946–63.

    Article  CAS  PubMed  Google Scholar 

  • Ferraro L, Tomasini MC, Beggiato S, Guerrini R, Salvadori S, Fuxe K, et al. Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders. Mini Rev Med Chem. 2009;9(12):1429–38.

    Article  CAS  PubMed  Google Scholar 

  • Hwang JI, Kim DK, Kwon HB, Vaudry H, Seong JY. Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates. Ann N Y Acad Sci. 2009;1163:169–78.

    Article  CAS  PubMed  Google Scholar 

  • Lafrance M, Roussy G, Belleville K, Maeno H, Beaudet N, Wada K, et al. Involvement of NTS2 receptors in stress-induced analgesia. Neuroscience. 2010;166(2):639–52.

    Article  CAS  PubMed  Google Scholar 

  • Martin S, Dicou E, Vincent JP, Mazella J. Neurotensin and the neurotensin receptor-3 in microglial cells. J Neurosci Res. 2005;81(3):322–6.

    Article  CAS  PubMed  Google Scholar 

  • Mustain WC, Rychahou PG, Evers BM. The role of neurotensin in physiologic and pathologic processes. Curr Opin Endocrinol Diabetes Obes. 2011;18(1):75–82.

    Article  CAS  PubMed  Google Scholar 

  • Opland D, Sutton A, Woodworth H, Brown J, Bugescu R, Garcia A, et al. Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity. Mol Metab. 2013;2(4):423–34.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Patel AB, Tsilioni I, Leeman SE, Theoharides TC. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci USA. 2016;113:E7049–58. Published online September 23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rabinowich L, Fishman S, Hubel E, Thurm T, Park WJ, Pewzner-Jung Y, et al. Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity. J Hepatol. 2015;62(1):175–81.

    Article  CAS  PubMed  Google Scholar 

  • Roussy G, Dansereau MA, Baudisson S, Ezzoubaa F, Belleville K, Beaudet N, et al. Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity. Mol Pain. 2009;5:38.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • St-Gelais F, Jomphe C, Trudeau LE. The role of neurotensin in central nervous system pathophysiology: what is the evidence? J Psychiatry Neurosci. 2006;31(4):229–45.

    PubMed  PubMed Central  Google Scholar 

  • Stolakis V, Kalafatakis K, Botis J, Zarros A, Liapi C. The regulatory role of neurotensin on the hypothalamic-anterior pituitary axons: emphasis on the control of thyroid-related functions. Neuropeptides. 2010;44(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  • Tsuchiya Y, Hatakeyama H, Emoto N, Wagatsuma F, Matsushita S, Kanzaki M. Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes. J Biol Chem. 2010;285(45):34371–81.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vincent JP, Mazella J, Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol Sci. 1999;20(7):302–9.

    Article  CAS  PubMed  Google Scholar 

  • Ye Y, Long X, Zhang L, Chen J, Liu P, Li H, et al. NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma. Oncotarget. 2016;7(43):70303–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhao D, Pothoulakis C. Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides. 2006;27(10):2434–44.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology and Pathophysiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, Canada

    Tooru Mizuno

Authors
  1. Tooru Mizuno
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tooru Mizuno .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Mizuno, T. (2018). Neurotensin Receptor (NTSR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_196

Download citation

Publish with us

Policies and ethics

Search

Navigation