Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SAMSN1 (SAM Domain, SH3 Domain, and Nuclear Localization Signal)

  • Yuan Xiao Zhu
  • A. Keith Stewart
  • Jaime O. ClaudioEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_191



Historical Background

The gene encoding SAMSN1 maps to human chromosome 21q11.2 in a region that is frequently disrupted by translocation events in hematopoietic malignancies (Mitelman et al. 1997). The full-length cDNA of human SAMSN1 was first identified and cloned in 2001 by two groups from myeloma cells and human cord blood–derived mast cells, named as HACS1 and Nash1, respectively (Claudio et al. 2001; Uchida et al. 2001). The predicted protein showed unique primary structure with a nuclear localization signal (NLS), a sterile alpha motif (SAM), and a Src homology 3 domain (SH3). SAMSN1 belongs to a novel family of scaffolding and adaptor proteins that includes SASH3/SLY/HACS2 (Beer et al. 2001) and SASH1/KIAA0790 (Zeller et al. 2003). The function of this novel family is not well characterized. The mouse, rat, and chimp orthologs have been identified, and unnamed protein homologs exist in chicken, zebrafish, and fly.

Expression of SAMSN1

SAMSN1 is expressed in...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Yuan Xiao Zhu
    • 1
  • A. Keith Stewart
    • 1
  • Jaime O. Claudio
    • 2
    Email author
  1. 1.Division of Hematology-OncologyMayo ClinicScottsdaleUSA
  2. 2.Toronto General Research InstituteUniversity Health NetworkTorontoCanada