Skip to main content

CSK-Homologous Kinase

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Advani G, Chueh AC, Lim YC, Dhillon A, Cheng H-C. Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression. Front Biol. 2015;10:195–202.

    Article  CAS  Google Scholar 

  • Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. J Biol Chem. 1995;270:1833–42.

    Article  PubMed  CAS  Google Scholar 

  • Ayrapetov MK, Nam NH, Ye G, Kumar A, Parang K, Sun G. Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation. J Biol Chem. 2005;280:25780–7.

    Article  PubMed  CAS  Google Scholar 

  • Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H. Identification and characterization of a novel tyrosine kinase from megakaryocytes. J Biol Chem. 1994;269:1068–74.

    PubMed  CAS  Google Scholar 

  • Chan KC, Lio DS, Dobson RCJ, Jarasrassamee B, Hossain MI, Roslee AK, Ia KK, Perugini MA, Cheng H-C. Development of the procedures for high yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK) – comparison of the catalytic activities of CHK and CSK. Protein Expr Purif. 2010;74:139–47.

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Tan SY, Petersson BF, Khor YM, Gopalakrishnan SK, Tan D. Occult recurrence of monomorphic epitheliotropic intestinal T-cell lymphoma and the role of MATK gene expression in diagnosis. Hematol Oncol. 2016. https://doi.org/10.1002/hon.2288.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheng H-C, Chong YP, Ia KK, Tan O, Mulhern TD. Csk homologous kinase. UCSD-Nature Molecule Pages. 2006. https://doi.org/10.1038/mp.a000705.01.

    Article  Google Scholar 

  • Chong YP, Mulhern TD, Zhu HJ, Fujita DJ, Bjorge JD, Tantiongco JP, Sotirellis N, Lio DS, Scholz G, Cheng HC. A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity. J Biol Chem. 2004;279:20752–66.

    Article  PubMed  CAS  Google Scholar 

  • Chong YP, Ia KK, Mulhern TD, Cheng HC. Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases. Biochim Biophys Acta. 2005a;1754:210–20.

    Article  PubMed  CAS  Google Scholar 

  • Chong YP, Mulhern TD, Cheng HC. C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases. Growth Factors. 2005b;23:233–44.

    Article  PubMed  CAS  Google Scholar 

  • Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC. C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases. J Biol Chem. 2006;281:32988–99.

    Article  PubMed  CAS  Google Scholar 

  • Chow LM, Davidson D, Fournel M, Gosselin P, Lemieux S, Lyu MS, Kozak CA, Matis LA, Veillette A. Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene. Oncogene. 1994;9:3437–48.

    PubMed  CAS  Google Scholar 

  • Dokmanovic M, Wu Y, Shen Y, Chen J, Hirsch DS, Wu WJ. Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. Cancer Biol Ther. 2014;15:1029–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gunn NJ, Gorman MA, Dobson RC, Parker MW, Mulhern TD. Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:336–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hamaguchi I, Yamaguchi N, Suda J, Iwama A, Hirao A, Hashiyama M, Aizawa S, Suda T. Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. Biochem Biophys Res Commun. 1996;224:172–9.

    Article  PubMed  CAS  Google Scholar 

  • Hinoue T, Weisenberger DJ, Lange CP, Shen H, Byun HM, Van Den Berg D, Malik S, Pan F, Noushmehr H, van Dijk CM, Tollenaar RA, Laird PW. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 2012;22:271–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Huang H, Li L, Wu C, Schibli D, Colwill K, Ma S, Li C, Roy P, Ho K, Songyang Z, Pawson T, Gao Y, Li SS. Defining the specificity space of the human SRC homology 2 domain. Mol Cell Proteomics. 2008;7:768–84.

    Article  PubMed  CAS  Google Scholar 

  • Huang K, Wang YH, Brown A, Sun G. Identification of N-terminal lobe motifs that determine the kinase activity of the catalytic domains and regulatory strategies of Src and Csk protein tyrosine kinases. J Mol Biol. 2009;386:1066–77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ia KK, Mills RD, Hossain MI, Chan K-C, Jarasrassamee B, Jorissen RN, Cheng H-C. Structural elements and allosteric mechanisms governing regulation and catalysis of Csk-family kinases and their inhibition of Src-family kinases. Growth Factors. 2010;28:329–50.

    Article  PubMed  CAS  Google Scholar 

  • Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC. Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of beta-synuclein as a potential CHK physiological substrate. Biochemistry. 2011;50:6667–77.

    Article  PubMed  CAS  Google Scholar 

  • Kim S, Zagozdzon R, Meisler A, Baleja JD, Fu Y, Avraham S, Avraham H. Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer. J Biol Chem. 2002;277:36465–70.

    Article  PubMed  CAS  Google Scholar 

  • Kim SO, Avraham S, Jiang S, Zagozdzon R, Fu Y, Avraham HK. Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors. Cancer. 2004;101:1018–27.

    Article  PubMed  CAS  Google Scholar 

  • Kuo SS, Moran P, Gripp J, Armanini M, Phillips HS, Goddard A, Caras IW. Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk. J Neurosci Res. 1994;38:705–15.

    Article  PubMed  CAS  Google Scholar 

  • Kuo SS, Armanini MP, Phillips HS, Caras IW. Csk and BatK show opposite temporal expression in the rat CNS: consistent with its late expression in development, BatK induces differentiation of PC12 cells. Eur J Neurosci. 1997;9:2383–93.

    Article  PubMed  CAS  Google Scholar 

  • Laffaire J, Everhard S, Idbaih A, Criniere E, Marie Y, de Reynies A, Schiappa R, Mokhtari K, Hoang-Xuan K, Sanson M, Delattre JY, Thillet J, Ducray F. Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis. Neuro-Oncology. 2011;13:84–98.

    Article  PubMed  CAS  Google Scholar 

  • Lamers MB, Antson AA, Hubbard RE, Scott RK, Williams DH. Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. J Mol Biol. 1999;285:713–25.

    Article  PubMed  CAS  Google Scholar 

  • Lee BC, Avraham S, Imamoto A, Avraham HK. Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice. Blood. 2006;108:904–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Levinson NM, Seeliger MA, Cole PA, Kuriyan J. Structural basis for the recognition of c-Src by its inactivator Csk. Cell. 2008;134:124–34.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Levinson NM, Visperas PR, Kuriyan J. The tyrosine kinase Csk dimerizes through its SH3 domain. PLoS One. 2009;4:e7683.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lin X, Ayrapetov MK, Lee S, Parang K, Sun G. Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk. Biochemistry. 2005;44:1561–7.

    Article  PubMed  CAS  Google Scholar 

  • Mitsuhashi H, Futai E, Sasagawa N, Hayashi Y, Nishino I, Ishiura S. Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells. J Neurochem. 2008;105:101–12.

    Article  PubMed  CAS  Google Scholar 

  • Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H. Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature. 1991;351:69–72.

    Article  PubMed  CAS  Google Scholar 

  • Nakayama Y, Kawana A, Igarashi A, Yamaguchi N. Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus. Exp Cell Res. 2006;312:2252–63.

    Article  PubMed  CAS  Google Scholar 

  • O’Hare T, Eide CA, Deininger MW. Persistent LYN signaling in imatinib-resistant, BCR-ABL-independent chronic myelogenous leukemia. J Natl Cancer Inst. 2008;100:908–9.

    Article  PubMed  CAS  Google Scholar 

  • Ogawa A, Takayama Y, Sakai H, Chong KT, Takeuchi S, Nakagawa A, Nada S, Okada M, Tsukihara T. Structure of the carboxyl-terminal Src kinase, Csk. J Biol Chem. 2002;277:14351–4.

    Article  PubMed  CAS  Google Scholar 

  • Okada M, Nakagawa H. A protein tyrosine kinase involved in regulation of pp60c-src function. J Biol Chem. 1989;264:20886–93.

    PubMed  CAS  Google Scholar 

  • Radhakrishnan Y, Shen X, Maile LA, Xi G, Clemmons DR. IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells. Mol Endocrinol. 2011;25:1636–49.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Samokhvalov I, Hendrikx J, Visser J, Belyavsky A, Sotiropolous D, Gu H. Mice lacking a functional chk gene have no apparent defects in the hematopoietic system. Biochem Mol Biol Int. 1997;43:115–22.

    PubMed  CAS  Google Scholar 

  • Seong J, Lu S, Ouyang M, Huang H, Zhang J, Frame MC, Wang Y. Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol. 2009;16:48–57.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shen X, Xi G, Radhakrishnan Y, Clemmons DR. Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells. Mol Cell Proteomics. 2009;8:1539–51.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tan SY, Ooi AS, Ang MK, Koh M, Wong JC, Dykema K, Ngeow J, Loong S, Gatter K, Tan L, Lim LC, Furge K, Tao M, Lim ST, Loong F, Cheah PL, Teh BT. Nuclear expression of MATK is a novel marker of type II enteropathy-associated T-cell lymphoma. Leukemia. 2011;25:555–7.

    Article  PubMed  CAS  Google Scholar 

  • Tan SY, Chuang SS, Tang T, Tan L, Ko YH, Chuah KL, Ng SB, Chng WJ, Gatter K, Loong F, Liu YH, Hosking P, Cheah PL, Teh BT, Tay K, Koh M, Lim ST. Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8alphaalpha phenotype. Leukemia. 2013;27:1688–96.

    Article  PubMed  CAS  Google Scholar 

  • Wong L, Lieser S, Chie-Leon B, Miyashita O, Aubol B, Shaffer J, Onuchic JN, Jennings PA, Woods Jr VL, Adams JA. Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J Mol Biol. 2004;341:93–106.

    Article  PubMed  CAS  Google Scholar 

  • Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods Jr VL, Jennings PA. Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol. 2005;351:131–43.

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi N, Nakayama Y, Urakami T, Suzuki S, Nakamura T, Suda T, Oku N. Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics. J Cell Sci. 2001;114:1631–41.

    PubMed  CAS  Google Scholar 

  • Zagozdzon R, Kaminski R, Fu Y, Fu W, Bougeret C, Avraham HK. Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner. Cell Signal. 2006;18:871–81.

    Article  PubMed  CAS  Google Scholar 

  • Zhu S, Bjorge JD, Cheng HC, Fujita DJ. Decreased CHK protein levels are associated with Src activation in colon cancer cells. Oncogene. 2008;27:2027–34.

    Article  PubMed  CAS  Google Scholar 

  • Zrihan-Licht S, Lim J, Keydar I, Sliwkowski MX, Groopman JE, Avraham H. Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. J Biol Chem. 1997;272:1856–63.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Heung-Chin Cheng .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Cheng, HC. et al. (2018). CSK-Homologous Kinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_185

Download citation

Publish with us

Policies and ethics