Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CSK-Homologous Kinase

  • Heung-Chin ChengEmail author
  • Gahana Advani
  • Mohammed Iqbal Hossain
  • Nadia L. Y. Ng
  • Ya Chee Lim
  • Anderly C. Chüeh
  • Mohd Aizuddin Kamaruddin
  • Yuh-Ping Chong
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_185


Historical Background

C-terminal Src kinase (Csk) and Csk-homologous kinase (also referred to as Csk-type kinase, Ctk) are the endogenous inhibitors of Src-family kinases (SFKs). Both inhibitors inactivate SFKs by phosphorylating their consensus C-terminal inhibitory tyrosine (corresponds to Tyr-527 in c-Src) that stabilizes the inactive SFK conformation (Fig. 1). The discovery of Csk can be traced back to an important study performed two decades ago (Okada and Nakagawa 1989). The study showed that Tyr-527 of c-Src did not undergo autophosphorylation. Rather, it was phosphorylated by a putative upstream tyrosine kinase that was originally termed neonatal brain type of protein tyrosine kinase (N-PTK) isolated from the membrane fraction...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Heung-Chin Cheng
    • 1
    Email author
  • Gahana Advani
    • 1
  • Mohammed Iqbal Hossain
    • 1
  • Nadia L. Y. Ng
    • 1
  • Ya Chee Lim
    • 1
    • 2
  • Anderly C. Chüeh
    • 3
  • Mohd Aizuddin Kamaruddin
    • 1
  • Yuh-Ping Chong
    • 4
  1. 1.Cell Signaling Research Laboratories, Department of Biochemistry and Molecular BiologyBio21 Molecular Science and Biotechnology Institute, University of MelbourneParkvilleAustralia
  2. 2.PAP Rashidah Sa’adatul Bolkiah Institute of Health SciencesUniversiti Brunei DarussalamGadongBrunei Darussalam
  3. 3.Systems Biology and Personalised Medicine DivisionThe Walter and Eliza Hall Institute of Medical ResearchParkvilleAustralia
  4. 4.Edinburgh Cancer Research CentreWestern General HospitalEdinburghUK