Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Grégory Tufo
  • Lorenzo Galluzzi
  • Guido Kroemer
  • Catherine BrennerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_175


Historical Background

The adenine nucleotide translocase (ANT) or ADP/ATP carrier belongs to the evolutionarily conserved family of mitochondrial carriers (for a recent review, see Palmieri 2014). ANT constitutes one of the most abundant proteins of the mitochondrial inner membrane (IM), in which it is inserted via six transmembrane helices. Both the C- and N-termini of ANT face the mitochondrial matrix. ANT was first characterized as an antiporter that mediates the export of ATP from the mitochondrial matrix to the intermembrane space together with the import of ADP from the intermembrane space to the matrix (Pfaff and Klingenberg 1968) (Fig. 1a). Its antiporter activity is electrogenic, as it drives the stoichiometric exchange of ATP 4− and ADP 3−. ANT may also act as an IM channel, playing a critical role in the permeabilization of mitochondrial membranes that accompanies regulated cell death, that is, intrinsic apoptosis as...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Grégory Tufo
    • 1
  • Lorenzo Galluzzi
    • 2
    • 3
    • 4
    • 5
  • Guido Kroemer
    • 6
    • 7
    • 8
    • 9
    • 10
    • 11
    • 12
  • Catherine Brenner
    • 1
    Email author
  1. 1.UMR-S 1180, INSERM, Université Paris-SudChâtenay-MalabryFrance
  2. 2.UMR1138, INSERMCentreFrance
  3. 3.Metabolomics PlatformInstitut Gustave RoussyVillejuifFrance
  4. 4.Pôle de BiologieHôpital Européen Georges PompidouHPFrance
  5. 5.Université Paris René DescartesParisFrance
  6. 6.Equipe Labellisée Ligue Nationale Contre le Cancer, Centre de Recherche des CordeliersParisFrance
  7. 7.Institut National de la Santé et de la Recherche Médicale (INSERM) U1138ParisFrance
  8. 8.Metabolomics and Cell Biology PlatformsGustave Roussy Cancer CampusVillejuifFrance
  9. 9.Université Paris Descartes, Sorbonne Paris CitéParisFrance
  10. 10.Université Pierre et Marie CurieParisFrance
  11. 11.Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HPParisFrance
  12. 12.Department of Women’s and Children’s HealthKarolinska Institute, Karolinska University HospitalStockholmSweden