Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Nazanine ModjtahediEmail author
  • Guido Kroemer
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_174


Historical Background

Apoptosis-inducing factor (AIF), which is confined to mitochondria of normal healthy cells, was initially described by Kroemer and coworkers (Susin et al. 1999) as the first caspase-independent death effector. Under conditions of cell death induction, AIF is released from mitochondria and translocates to the nucleus where it contributes to chromatin condensation and DNA fragmentation, two features that are classically associated with apoptosis (Hangen et al. 2010a). Since its initial discovery, the structure of the AIF protein has been resolved and the AIFgene has been subjected to genetic manipulations in mice, flies, nematodes, and yeast, revealing the phylogenetically conserved contribution of AIF to cell death, as well as its crucial role in...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institut National de la Santé et de la Recherche Médicale (INSERM) U1030, Institut Gustave RoussyVillejuifFrance
  2. 2.Gustave Roussy Cancer CampusVillejuifFrance
  3. 3.Faculty of MedicineUniversité Paris-SaclayKremlin-BicêtreFrance
  4. 4.Equipe Labellisée Ligue Nationale Contre le Cancer, Centre de Recherche des CordeliersParisFrance
  5. 5.Institut National de la Santé et de la Recherche Médicale (INSERM) U1138ParisFrance
  6. 6.Metabolomics and Cell Biology PlatformsGustave Roussy Cancer CampusVillejuifFrance
  7. 7.Université Paris Descartes, Sorbonne Paris CitéParisFrance
  8. 8.Université Pierre et Marie CurieParisFrance
  9. 9.Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HPParisFrance
  10. 10.Department of Women’s and Children’s HealthKarolinska Institute, Karolinska University HospitalStockholmSweden