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Encyclopedia of Signaling Molecules pp 3999–4010Cite as

Phospholipase D

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Synonyms

Phospholipase D1; Phospholipase D2; PLD1; PLD2

Historical Background

PLD was first characterized in vegetables by Hanahan and Chaikoff (1947) and changes in its lipase activity have been reported in relation to lipid metabolism in seed germination and lipid turnover and lipid composition during plant development and in membrane deterioration as a result of stress injuries. PLD was first cloned from cabbage (Brassica oleracea), castor bean (Ricinus communis L.), rice (Oryza sativa L.), corn (Zea mays L.), and rockcress (Arabidopsis), which code for an 808-amino acid cytosolic protein of ∼90 kDa MW, as mentioned in the review by (Cockcroft 1996). Plant PLD is linked to membrane deterioration during plant senescence as a result of decreased membrane phospholipid content. Additionally, PLD is present in large quantities in bacteria (Streptomyces), yeast (Saccharomyces cerevisiae), and mammalian cells.

Within mammalian sources, PLD has been found in a variety of cell types...

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References

  • Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, Beaven MA. Activation of RBL-2 H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol. 2004;24:6980–92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cockcroft S. Phospholipase D: regulation by GTPases and protein kinase C and physiological relevance. Prog Lipid Res. 1996;35:345–70.

    Article  PubMed  CAS  Google Scholar 

  • Du G, Altshuller YM, Kim Y, Han JM, Ryu SH, Morris AJ, Frohman MA. Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol Biol Cell. 2000;11:4359–68.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Exton JH. Phospholipase D. Ann N Y Acad Sci. 2000;905:61–8.

    Article  PubMed  CAS  Google Scholar 

  • Foster DA, Xu L. Phospholipase D in cell proliferation and cancer. Mol Cancer Res. 2003;1:789–800.

    PubMed  CAS  Google Scholar 

  • Frohman MA, Sung TC, Morris AJ. Mammalian phospholipase D structure and regulation. Biochim Biophys Acta. 1999;1439:175–86.

    Article  PubMed  CAS  Google Scholar 

  • Frondorf K, Henkels KM, Frohman MA, Gomez-Cambronero J. Phosphatidic acid (PA) is a leukocyte chemoattractant that acts through S6 kinase signaling. J Biol Chem. 2010;285:15837–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gomez-Cambronero J. New concepts in phospholipase D signaling in inflammation and cancer. Sci World J. 2010;10:1356–69.

    Article  CAS  Google Scholar 

  • Gomez-Cambronero J, Di Fulvio M, Knapek K. Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis. J Leukoc Biol. 2007;82:272–81.

    Article  PubMed  CAS  Google Scholar 

  • Hammond SM, Jenco JM, Nakashima S, Cadwallader K, Gu Q, Cook S, Nozawa Y, Prestwich GD, Frohman MA, Morris AJ. Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem. 1997;272:3860–8.

    Article  PubMed  CAS  Google Scholar 

  • Hanahan DJ, Chaikoff IL. The phosphorous-containing lipids of the carrot. J Biol Chem. 1947;168:233–40.

    PubMed  CAS  Google Scholar 

  • Iyer SS, Agrawal RS, Thompson CR, Thompson S, Barton JA, Kusner DJ. Phospholipase D1 regulates phagocyte adhesion. J Immunol. 2006;176:3686–96.

    Article  PubMed  CAS  Google Scholar 

  • Katayama K, Kodaki T, Nagamachi Y, Yamashita S. Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver. Biochem J. 1998;329(Pt 3):647–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Knapek K, Frondorf K, Post J, Short S, Cox D, Gomez-Cambronero J. The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol. 2010;30:4492–506.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009;19:1916–20.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Min DS, Kim EG, Exton JH. Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3 T3 fibroblasts. J Biol Chem. 1998;273:29986–94.

    Article  PubMed  CAS  Google Scholar 

  • Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009;324:384–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Park SH, Chun YH, Ryu SH, Suh PG, Kim H. Assignment of human PLD1 to human chromosome band 3q26 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1998a;82:224.

    Article  PubMed  CAS  Google Scholar 

  • Park SH, Ryu SH, Suh PG, Kim H. Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1998b;82:225.

    Article  PubMed  CAS  Google Scholar 

  • Peng HJ, Henkels KM, Mahankali M, Bubulya P, Dinauer MC, Gomez-Cambronero J. The dual effect of Rac2 on PLD2 regulation that explains both onset and termination of chemotaxis. Mol Cell Biol. 2011. https://doi.org/10.1128/MCB.01348-10.

  • Porcelli AM, Ghelli A, Hrelia S, Rugolo M. Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. Cell Signal. 2002;14(1):75–81.

    Article  PubMed  CAS  Google Scholar 

  • Powner DJ, Wakelam MJ. The regulation of phospholipase D by inositol phospholipids and small GTPases. FEBS Lett. 2002;531:62–4.

    Article  PubMed  CAS  Google Scholar 

  • Powner DJ, Hodgkin MN, Wakelam MJ. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2 H3 cells. Mol Biol Cell. 2002;13:1252–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rossi F, Grzeskowiak M, Della Bianca V, Calzetti F, Gandini G. Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils. Biochem Biophys Res Commun. 1990;168:320–7.

    Article  PubMed  CAS  Google Scholar 

  • Steed PM, Clark KL, Boyar WC, Lasala DJ. Characterization of human PLD2 and the analysis of PLD isoform splice variants. FASEB J. 1998;12:1309–17.

    Article  PubMed  CAS  Google Scholar 

  • Su W, Chen Q, Frohman MA. Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis. Future Oncol. 2009;5:1477–86.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA

    Julian Gomez-Cambronero & Karen M. Henkels

Authors
  1. Julian Gomez-Cambronero
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  2. Karen M. Henkels
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Corresponding author

Correspondence to Julian Gomez-Cambronero .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gomez-Cambronero, J., Henkels, K.M. (2018). Phospholipase D. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_15

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