Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Phospholipase D

  • Julian Gomez-CambroneroEmail author
  • Karen M. Henkels
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_15


Historical Background

PLD was first characterized in vegetables by Hanahan and Chaikoff (1947) and changes in its lipase activity have been reported in relation to lipid metabolism in seed germination and lipid turnover and lipid composition during plant development and in membrane deterioration as a result of stress injuries. PLD was first cloned from cabbage (Brassica oleracea), castor bean (Ricinus communis L.), rice (Oryza sativa L.), corn (Zea mays L.), and rockcress (Arabidopsis), which code for an 808-amino acid cytosolic protein of ∼90 kDa MW, as mentioned in the review by (Cockcroft 1996). Plant PLD is linked to membrane deterioration during plant senescence as a result of decreased membrane phospholipid content. Additionally, PLD is present in large quantities in bacteria (Streptomyces), yeast (Saccharomyces cerevisiae), and mammalian cells.

Within mammalian sources, PLD has been found in a variety of cell types...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyWright State University School of MedicineDaytonUSA