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Encyclopedia of Signaling Molecules pp 886–893Cite as

CD40

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Synonyms

Bp50; CDW40; MGC9013; p50; TNFRSF5

Historical Background

CD40, a 50kDa transmembrane member of the tumor-necrosis factor (TNF) receptor (TNFR) superfamily of molecules, plays a key role in adaptive immune responses. This includes contact-mediated signals to B cells from activated T lymphocytes, as well as costimulatory interactions between T cells and other antigen-presenting cells (APC), such as dendritic cells (DC) and macrophages. CD40-mediated interactions between B and T cells make important contributions to the development of an optimal humoral memory response (Bishop 2009).

CD40 lacks intrinsic enzymatic activity and therefore depends on cytoplasmic (CY) adaptor molecules referred to as TNFR-associated factors (TRAFs) for delivery of signals to the cytoplasm. CD40 engagement on B cells stimulates the binding of TRAFs to the CD40 CY domain. This in turn stimulates kinase activity and gene expression pathways that lead to a variety of responses, including B cell survival...

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References

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Author information

Authors and Affiliations

  1. Departments of Microbiology and Internal Medicine, The University of Iowa and VAMC, 375 Newton Rd, Iowa City, IA, 52242, USA

    Gail A. Bishop

  2. Department of Microbiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Bruce S. Hostager

Authors
  1. Gail A. Bishop
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  2. Bruce S. Hostager
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Corresponding author

Correspondence to Gail A. Bishop .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Bishop, G.A., Hostager, B.S. (2018). CD40. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_148

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