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NFAT

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Synonyms

NFATc1 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1; NFAT2; NFATc, NFAT cytoplasmic); NFATc2 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2; NFAT1; NFATp, NFAT preexisting); NFATc3 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3; NFAT4; NFATx); NFATc4 (Nuclear factor of activated T-cells cytoplasmic calcineurin dependent 4, NFAT3); NFAT5 (Nuclear factor of activated T-cells 5; TonEBP, Tonicity-responsive enhancer binding protein; OREBP, Osmotic response element-binding protein)

Historical Background

The gene encoding for the first nuclear factor of activated T cells (NFAT) protein was cloned more than 20 years ago and termed NFATp, as it was shown to be “preexistent” in the cytosol of resting T cells. In activated T cells, NFATp interacted with the transcription factors Fos and Jun in the nucleus to induce the expression of interleukin (IL-) 2 (Jain et al. 1993). Soon after, new members of the NFAT...

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NFAT, Fig. 1
NFAT, Fig. 2

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Correspondence to Fernando Macian .

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Ames, R.Y., Valdor, R., Abe, B.T., Macian, F. (2018). NFAT. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_141

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