NFATc1 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1; NFAT2; NFATc, NFAT cytoplasmic); NFATc2 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2; NFAT1; NFATp, NFAT preexisting); NFATc3 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3; NFAT4; NFATx); NFATc4 (Nuclear factor of activated T-cells cytoplasmic calcineurin dependent 4, NFAT3); NFAT5 (Nuclear factor of activated T-cells 5; TonEBP, Tonicity-responsive enhancer binding protein; OREBP, Osmotic response element-binding protein)
The gene encoding for the first nuclear factor of activated T cells (NFAT) protein was cloned more than 20 years ago and termed NFATp, as it was shown to be “preexistent” in the cytosol of resting T cells. In activated T cells, NFATp interacted with the transcription factors Fos and Jun in the nucleus to induce the expression of interleukin (IL-) 2 (Jain et al. 1993). Soon after, new members of the...
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