Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

HB-EGF (Heparin-Binding EGF-Like Growth Factor)

  • Ryo Iwamoto
  • Eisuke MekadaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_127


Historical Background

Since the discovery of epidermal growth factor (EGF) in 1962, a total of seven mammalian ligands that bind the EGF receptor (EGFR/ErbB1) have been identified, including transforming growth factor-α (TGFα), amphiregulin (ARG), betacellulin (BTC), epiregulin (ERG), epigen (EPG), and heparin-binding EGF-like growth factor (HB-EGF) (Harris et al. 2003). Historically, HB-EGF was the fourth growth factor to be identified among EGFR-ligands. Major findings regarding HB-EGF are:
  • Discovery of HB-EGF (Higashiyama et al. 1991)

  • Identification of HB-EGF as the diphtheria toxin receptor (DTR) (Naglich et al. 1992; Iwamoto et al. 1994)

  • Identification of HB-EGF’s major role in EGFR transactivation (Prenzel et al. 1999)

  • Establishment of HB-EGF-null mouse lines (Iwamoto et al. 2003; Jackson et al. 2003)

  • Proof of the physiological significance of HB-EGF...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Cell Biology, Research Institute for Microbial DiseasesOsaka UniversitySuita, OsakaJapan