Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • David W. LitchfieldEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_111


Historical Background

CKIP-1 (CK2-interacting protein-1) was initially described on the basis of its interactions with protein kinase CK2 (Bosc et al. 2000). In this respect, the first publication on CKIP-1 described isolation of a cDNA encoding this novel protein from a human B-cell cDNA library using a yeast two-hybrid screen to identify interaction partners of protein kinase CK2. Interactions between CK2 and CKIP-1 were confirmed by co-immunoprecipitation experiments and in vitro interaction assays using recombinant and in vitro translated proteins. Prior to that report, a partial cDNA encoding its C-terminal 72 amino acids had been isolated from a mouse embryo cDNA library, using a yeast two-hybrid screen to identify interaction partners for the leucine zipper region of the c-Jun...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biochemistry, Schulich School of Medicine and DentistryThe University of Western OntarioLondonCanada
  2. 2.Department of Oncology, Schulich School of Medicine and DentistryThe University of Western OntarioLondonCanada