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Encyclopedia of Signaling Molecules pp 708–717Cite as

Casein Kinase II

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Synonyms

Casein kinase 2; CKII; CSNK2; Protein kinase CK2

Historical Background

Protein kinase CK2 was isolated almost 60 years ago on the basis of its ability to phosphorylate the milk protein casein (Allende and Allende 1995; Venerando et al. 2014). As a result, it was originally designated “casein kinase II,” though this misnomer is less frequently used because of the lack of physiological significance for the phosphorylation of casein by CK2. Ironically, the enzyme/substrate relationship between CK2 and casein illustrates somewhat of a recurring theme. In this respect, over 50 years of research on CK2 has resulted in a compilation of a very large number of putative CK2 substrates, while the functional analysis of these phosphorylation events has lagged comparatively behind. In large part, the identification of many CK2 substrates has been promoted by its relatively simple and somewhat unique preference for acidic specificity determinants (S/T-X-X- E/D/pS/pY) (Meggio and Pinna 2003)...

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Authors and Affiliations

  1. Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, N6A 5C1, Canada

    Jacob P. Turowec, Nicole A. St. Denis & David W. Litchfield

  2. Department of Oncology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, N6A 5C1, Canada

    David W. Litchfield

Authors
  1. Jacob P. Turowec
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  2. Nicole A. St. Denis
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  3. David W. Litchfield
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Corresponding author

Correspondence to David W. Litchfield .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Turowec, J.P., St. Denis, N.A., Litchfield, D.W. (2018). Casein Kinase II. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_110

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