Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Proliferating Cell Nuclear Antigen

  • Rashmi Maruti HosalkarEmail author
  • Niharika Swain
  • Jayesh S. Khivasara
  • Samapika Routray
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_102006


Historical Background

Proliferation cell nuclear antigen (PCNA) was identified by two separate groups of researchers performing separate studies. Initially it was identified in a study on systemic lupus erythematous patients as protein present in the nucleus of dividing cells. During the same period, in another study, it was observed as a protein synthesized during S-phase of cell cycle and was termed as cyclin. However, further researches demonstrated that the proteins discovered in the above two studies were same and now are known by PCNA (Strzalka and Ziemienowicz 2011).

Gene Transcription

In 1989, Travali and coworkers molecularly cloned and sequenced human PCNA gene (Travali et al. 1989). It was sequenced from BamHi restriction site located 2.8 kb upstream from the site for transcription initiation (CAP site). It consists of six exons separated by five introns. Human PCNA gene has features that are...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Rashmi Maruti Hosalkar
    • 1
    • 2
    Email author
  • Niharika Swain
    • 3
  • Jayesh S. Khivasara
    • 4
  • Samapika Routray
    • 5
  1. 1.Indian Association of Oral and Maxillofacial PathologistsMumbaiIndia
  2. 2.Maharashtra State Dental CouncilMumbaiIndia
  3. 3.MGM Dental College and HospitalNavi MumbaiIndia
  4. 4.Mahatma Gandhi Cancer HospitalSangliIndia
  5. 5.Department of Dental Surgery, All India Institute of Medical SciencesBhubaneswarIndia