Proliferating Cell Nuclear Antigen
Proliferation cell nuclear antigen (PCNA) was identified by two separate groups of researchers performing separate studies. Initially it was identified in a study on systemic lupus erythematous patients as protein present in the nucleus of dividing cells. During the same period, in another study, it was observed as a protein synthesized during S-phase of cell cycle and was termed as cyclin. However, further researches demonstrated that the proteins discovered in the above two studies were same and now are known by PCNA (Strzalka and Ziemienowicz 2011).
In 1989, Travali and coworkers molecularly cloned and sequenced human PCNA gene (Travali et al. 1989). It was sequenced from BamHi restriction site located 2.8 kb upstream from the site for transcription initiation (CAP site). It consists of six exons separated by five introns. Human PCNA gene has features that are...
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