Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Myoglobin (Mb)

  • Niharika SwainEmail author
  • Shilpa Patel
  • Rashmi Maruti Hosalkar
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_102005


Historical Background

Myoglobin (Mb) is a monomeric, cytoplasmic hemoprotein with rich and varied history, thus becoming an object of renewed interest owing to its role beyond those previously described. In 1987, Mörner first identified and differentiated Mb from hemoglobin (Hb) by their differences in absorption spectra and further termed it as myochrome (Garry and Mammen 2007). Interestingly, it is the first protein upon which a three-dimensional structure was determined. The notation Mb was introduced by Günther, who confirmed the results of Mörner in 1921 (Hendgen-Cotta et al. 2010). The term Mb has been given owing to its functional and structural similarity with Hb. For a long time, it was believed that expression of Mb in vertebrates was restricted to muscle tissue like cardiomyocytes, oxidative skeletal myofibers, and vascular smooth muscle cells and its associated diseases (Hendgen-Cotta et al. 2010). However, recent studies have...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Niharika Swain
    • 1
    Email author
  • Shilpa Patel
    • 1
  • Rashmi Maruti Hosalkar
    • 2
    • 3
  1. 1.MGM Dental College and HospitalNavi MumbaiIndia
  2. 2.Indian Association of Oral and Maxillofacial PathologistsMumbaiIndia
  3. 3.Maharashtra State Dental CouncilMumbaiIndia