Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Niharika SwainEmail author
  • Jigna Pathak
  • Shilpa Patel
  • Rashmi Maruti Hosalkar
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_102000


Historical Background

Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endopeptidases which are capable of degrading all extracellular matrix (ECM) components as well as process a variety of non-ECM substrates. They are responsible for physiological and pathological tissue remodeling. They are expressed in neutrophils, endothelial cells, eosinophils, macrophages, and T lymphocytes (Fanjul-Fernández et al. 2010; Iyer et al. 2012).

In 1962, Woessner demonstrated a protein enzyme in mammalian uterus that could degrade collagen. Later on Jerome Gross and Charles Lapiere identified a matrix metalloproteinase using a biochemical approach in which they showed collagenolytic activity in the skin, gut, and gills of the tadpole during metamorphosis. Later the International Union of Biochemistry and Molecular Biology designated the family with a unique...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Niharika Swain
    • 1
    Email author
  • Jigna Pathak
    • 1
  • Shilpa Patel
    • 1
  • Rashmi Maruti Hosalkar
    • 2
    • 3
  1. 1.MGM Dental College and HospitalNavi MumbaiIndia
  2. 2.Indian Association of Oral and Maxillofacial PathologistsMumbaiIndia
  3. 3.Maharashtra State Dental CouncilMumbai, MaharashtraIndia