Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SLC34

  • Ian ForsterEmail author
  • Andreas Werner
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101997
How to cite

Synonyms

 Inorganic phosphate transporter type II (a, b, or c);  NaPi-IIa;  NaPi-IIb;  NaPi-IIc;  NPT2a;  NPT2b;  NPT2c;  Sodium/phosphate cotransporter type 2;  Solute carrier family 34 (sodium phosphate)

Historical Background

Phosphorus is one of the six essential elements for life. Molecules containing anionic phosphate (PO43−) are constituents of genetic material (DNA, RNA) and are an essential building block of phospholipid membranes, bones, and teeth; high-energy phosphate bonds drive cell energetics via ATP/ADP hydrolysis; phosphorylation/dephosphorylation reactions are key events in intracellular signaling, and phosphate acts as an intra- and extracellular pH buffer. In mammals, phosphate is obtained from the diet in the form of inorganic phosphate (Pi) that exists in solution as negatively charged mono- (H2PO4−) and divalent (HPO42−) ions in the physiological pH range. As such Pimust be actively transported “uphill” across the cell membrane from the external medium against...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Florey Institute for Neuroscience and Mental HealthParkvilleAustralia
  2. 2.Institute for Cell and Molecular BiosciencesUniversity of Newcastle upon TyneNewcastle upon TyneUK